{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:53:18Z","timestamp":1774565598734,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/10599\u20103"],"award-info":[{"award-number":["2021\/10599\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2024\/13125\u20100"],"award-info":[{"award-number":["2024\/13125\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["383955\/2024\u20106"],"award-info":[{"award-number":["383955\/2024\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["409184\/2022\u20105"],"award-info":[{"award-number":["409184\/2022\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n There is a lack of contemporary studies addressing the prevalence rates and antifungal susceptibility of bloodstream infections (BSI) caused by rare yeasts (RY) from the\n Saccharomycotina<\/jats:italic>\n subphylum.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n This 16\u2010year multicentre study (2007\u20132023) aimed to assess the prevalence and antifungal susceptibility of rare yeasts isolated from BSIs in 28 Brazilian tertiary care hospitals.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Yeasts from the\n Saccharomycotina<\/jats:italic>\n subphylum, excluding common\n Candida<\/jats:italic>\n species and Basidiomycota, were selected from BSI episodes. Species were identified using proteomics and molecular methods. Antifungal susceptibility testing was performed by EUCAST broth microdilution.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 2655 BSI episodes, 100 (3.76%) involved rare yeasts. Prevalence showed a slight, non\u2010significant increase from 3.16% (2007\u20132015) to 4.17% (2016\u20132023;\n p<\/jats:italic>\n \u2009=\u20090.183). A total of 11 genera and 20 species were identified, with\n Clavispora lusitaniae<\/jats:italic>\n (20%),\n Wickerhamomyces anomalus<\/jats:italic>\n (16%),\n Candida haemulonii<\/jats:italic>\n (14%) and\n Candida duobushaemulonii<\/jats:italic>\n (12%) being the most frequent species. Eight species, including\n Pichia kluyveri<\/jats:italic>\n and\n Kodamaea ohmeri<\/jats:italic>\n , appeared only in the latter period. Most rare yeasts showed low MICs to amphotericin B and anidulafungin, except for\n Clavispora lusitaniae<\/jats:italic>\n ,\n Candida haemulonii<\/jats:italic>\n and\n Candida duobushaemulonii<\/jats:italic>\n , which were less susceptible to amphotericin B.\n Wickerhamomyces anomalus<\/jats:italic>\n and\n Candida duobushaemulonii<\/jats:italic>\n also showed reduced susceptibility to fluconazole.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This study provides valuable insights into the prevalence rates, species distribution and antifungal susceptibility of rare yeasts causing BSIs in tertiary care hospitals. Our findings highlight the need for continuous surveillance, incorporation of new diagnostic and tailored therapeutic strategies to mitigate morbidity and mortality due to invasive infections caused by emerging fungal pathogens.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/myc.70149","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:30:49Z","timestamp":1772764249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence Rates, Species Distribution and Antifungal Susceptibility of Rare\n \n Candida<\/i>\n <\/scp>\n and Related\n \n Saccharomycotina<\/i>\n <\/scp>\n Yeasts Causing Bloodstream Infections in 28 Medical Centres"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4700-6605","authenticated-orcid":false,"given":"Carolina Palamin","family":"Buonafine","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio Especial de Micologia, Escola Paulista de Medicina\u2010Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Antimicrobial Resistance Institute of S\u00e3o Paulo (ARIES) S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2143-0515","authenticated-orcid":false,"given":"Alexander E.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Especial de Micologia, Escola Paulista de Medicina\u2010Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3739-9230","authenticated-orcid":false,"given":"Larissa Molina","family":"Favarello","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Especial de Micologia, Escola Paulista de Medicina\u2010Universidade Federal de S\u00e3o Paulo S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-1982","authenticated-orcid":false,"given":"Regielly C. 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