{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:14:34Z","timestamp":1771341274799,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Invasive fungal infections (IFI) are a prominent cause of morbidity and mortality among patients with haematological malignancies (HMs). Diagnostic work\u2010up excluding IFI is mandatory in case of persistent fever while antifungal treatment (AFT) is started.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to describe antifungal prophylaxis (AFP) and AFT among haematological patients with IFI managed in clinical practice, focusing on microbiological and radiological characteristics, 30\u2010day outcome and therapeutic options after AFT failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We enrolled 461 consecutive adult and paediatric patients with HMs, in which an intravenous AFT was started from September 2019 to December 2021. After serum galactomannan (GM) and chest CT scan, they were stratified as presenting with proven, probable, and possible IFI according to 2008 EORTC\u2010MSG criteria. Fungal isolates were detected from culture tests in 17.5% and from biopsy in 1.5% of patients. Mould active and non\u2010active AFP was used in 42.3% and 16.5% of cases, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Use of AFP significantly impact on serum GM negativity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for mould active and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04 for mould non active, respectively). Use of mould non\u2010active prophylaxis significantly correlates with radiological imaging (typical\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0037, IC (0.370\u20130.825) and negative \u2010\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0031, IC (0.241\u20130.750)). Toxicity, progression, and drug interaction were responsible for therapy change in 58 (12%) patients: 18 patients with proven\/probable IFI needed multiple courses of AFT. At 30\u2009days from starting AFT, overall mortality with IFI was 23\/461 (5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this observational study, we recorded an impact of AFP on serum GM results and radiological imaging. Need of AFT should be carefully evaluated, as diagnostic work\u2010up might be affected not only by specific disease risk but also by previous AFP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70150","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:15:20Z","timestamp":1768036520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterisation of Antifungal Prophylaxis and Therapy Among Inpatients With Haematological Malignancies in Non\u2010Research Clinical Setting: A Multicentre Italian Experience"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5661-2338","authenticated-orcid":false,"given":"Criscuolo","family":"Marianna","sequence":"first","affiliation":[{"name":"Dipartimento di Laboratorio e Scienze Ematologiche Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonanni","family":"Matteo","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Fondazione \u2018G. Pascale\u2019 IRCCS, Hematology\u2010Oncology &amp; Stem Cell Transplantation Unit  Napoli Italy"},{"name":"Dipartimento di Scienze Radiologiche Ed Ematologiche Universit\u00e0 Cattolica del Sacro Cuore  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martino","family":"Giordana","sequence":"additional","affiliation":[{"name":"Sapienza University  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farina","family":"Francesca","sequence":"additional","affiliation":[{"name":"Hematology and Bone Marrow Transplantation IRCCS San Raffaele Scientific Institute  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Verga","family":"Luisa","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marchesi","family":"Francesco","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplant Unit IRCCS Regina Elena National Cancer Institute  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basilico","family":"Claudia","sequence":"additional","affiliation":[{"name":"UO di Ematologia, Ospedale di Circolo \u2010 Fondazione Macchi, ASST Settelaghi  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Del Principe Maria","family":"Ilaria","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention University of Rome Tor Vergata  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tisi Maria","family":"Chiara","sequence":"additional","affiliation":[{"name":"Hematology Unit San Bortolo Hospital, AULSS 8 Berica  Vicenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cattaneo","family":"Chiara","sequence":"additional","affiliation":[{"name":"Hematology Division ASST\u2010Spedali Civili di Brescia  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Picardi","family":"Marco","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonuomo","family":"Valentina","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin  Turin Italy"},{"name":"Department of Medicine, Section of Hematology University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fracchiolla","family":"Nicola","sequence":"additional","affiliation":[{"name":"UOC Ematologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-1310","authenticated-orcid":false,"given":"Candoni","family":"Anna","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Section of Hematology University of Modena and Reggio Emilia, Azienda Ospedaliero\u2010Universitaria di Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perruccio","family":"Katia","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Hematology Ospedale Santa Maria Della Misericordia  Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanzani","family":"Marta","sequence":"additional","affiliation":[{"name":"Hematopoietic Stem Cell Transplantation and Cellular Therapy, Hematology Unit Ca' Foncello Hospital  Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8698-9547","authenticated-orcid":false,"given":"Cesaro","family":"Simone","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Oncology, Department of Mother and Child Azienda Ospedaliera Universitaria Integrata  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanci","family":"Rosa","sequence":"additional","affiliation":[{"name":"SOD Complessa di Ematologia Azienda Ospedaliero\u2010Universitaria Careggi e Universit\u00e0 di Firenze  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dargenio","family":"Michela","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplan Unit  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Forghieri","family":"Fabio","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Section of Hematology University of Modena and Reggio Emilia, Azienda Ospedaliero\u2010Universitaria di Modena  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ballanti","family":"Stelvio","sequence":"additional","affiliation":[{"name":"Sezione di Ematologia e Immunologia Clinica Ospedale Santa Maria Della Misericordia  Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cudillo","family":"Laura","sequence":"additional","affiliation":[{"name":"Hematology San Giovanni Addolorata Hospital  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuccaro","family":"Annarosa","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Fondazione \u2018G. Pascale\u2019 IRCCS, Hematology\u2010Oncology &amp; Stem Cell Transplantation Unit  Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carraro","family":"Francesca","sequence":"additional","affiliation":[{"name":"Pediatric Oncology\u2010Hematology Regina Margherita Pediatric Hospital  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zama","family":"Daniele","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Alma Mater Studiorum, University of Bologna  Bologna Italy"},{"name":"Pediatric Emergency Unit IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armiento","family":"Daniele","sequence":"additional","affiliation":[{"name":"University Campus Bio\u2010Medico and, Fondazione Policlinico Universitario Campus Bio\u2010Medico  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garzia Maria","family":"Grazia","sequence":"additional","affiliation":[{"name":"Department of Hematology Hematology San Camillo Forlanini Hospital  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spolzino","family":"Angelica","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery University of Parma and Hematology, Azienda Ospedaliero\u2010Universitaria di Parma  Parma Italy"},{"name":"Onco Hematology, Department of Oncology Veneto Institute of Oncology IOV, IRCCS  Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Busca","family":"Alessandro","sequence":"additional","affiliation":[{"name":"Department of Hematology and Stem Cell Transplant Unit Azienda Ospedaliera Universitaria Citta' Della Salute e Della Scienza  Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pagano","family":"Livio","sequence":"additional","affiliation":[{"name":"Sezione di Ematologia, Dipartimento di Scienze Radiologiche Ed Ematologiche Universit\u00e0 Cattolica del Sacro Cuore  Roma Italy"},{"name":"Dipartimento di Diagnostica Per Immagini, Radioterapia Oncologica Ed Ematologia Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2018.02.012"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.012054"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2010.01.002"},{"key":"e_1_2_9_5_1","first-page":"3221","article-title":"European Guidelines for Primary Antifungal Prophylaxis in Adult Haematology Patients: Summary of the Updated Recommendations From the European Conference on Infections in Leukaemia","volume":"73","author":"Maertens J. A.","year":"2018","journal-title":"Journal of Antimicrobial Chemotherapy"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2023.2290639"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000531044"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061094"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.25477"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/657065"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03685.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13715"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.175"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15591"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.70150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.70150","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.70150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:28:01Z","timestamp":1771338481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.70150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/myc.70150"],"URL":"https:\/\/doi.org\/10.1111\/myc.70150","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70150"}}