{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:43:35Z","timestamp":1790117015299,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sporotrichosis is a dimorphic fungal infection of increasing global relevance. Although usually cutaneous or lymphocutaneous, disseminated disease occurs in immunocompromised hosts. Large\u2010scale data on its epidemiology, treatment and outcomes remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterise the clinical features, comorbidities, antifungal prescribing patterns and one\u2010year mortality associated with sporotrichosis, with emphasis on patients with HIV and other forms of immunosuppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>We performed a retrospective global cohort study using the TriNetX Research Network. Adults (\u2265\u200918\u2009years) diagnosed with sporotrichosis were identified using ICD\u20109\/10 codes (1995\u20132024). Demographics, comorbidities, laboratory parameters and antifungal prescriptions were analysed. The primary outcome was all\u2010cause mortality at 1\u2009year. Secondary outcomes included hospitalisation and admission to the intensive care unit (ICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 2124 adults, the mean age was 52\u2009years, and 56.5% were female. Nearly half of the cases originated internationally, with the southeastern United States accounting for the majority of domestic cases. Neoplasms (25%) and diabetes (11%) were the most common comorbidities. Lymphocutaneous disease was uncommon (9%), and disseminated infection occurred in 1% of cases. One\u2010year mortality was 17%, with a higher risk among older adults and those with neoplasms, lymphocutaneous or disseminated infection or hyperferritinemia. Seventeen patients (0.8%) had HIV and were more likely to have pulmonary or disseminated disease. Itraconazole was the most commonly prescribed antifungal (52%), while the use of amphotericin B remained low (&lt;\u20092%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sporotrichosis causes substantial global mortality. Outcomes appear driven by host factors and gaps in guideline\u2010based management. Earlier recognition, optimised antifungal therapy, and use of inflammatory markers to guide risk stratification may improve outcomes and inform prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70152","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:16:25Z","timestamp":1772993785000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiology and Outcomes of Sporotrichosis: A Descriptive Real\u2010World Analysis From a Global Cohort"],"prefix":"10.1111","volume":"69","author":[{"given":"Samantha","family":"Schapiro","sequence":"first","affiliation":[{"name":"Saint Joseph Hospital Internal Medicine Residency  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Pulciano","sequence":"additional","affiliation":[{"name":"Rocky Vista University College of Osteopathic Medicine  Parker Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0602-5934","authenticated-orcid":false,"given":"Julian","family":"Galindo\u2010Ramirez","sequence":"additional","affiliation":[{"name":"Internal Medicine Residency Program University of Texas Rio Grande Valley  Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Rau","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine University of Colorado Denver  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1159-429X","authenticated-orcid":false,"given":"Jose","family":"Tuells","sequence":"additional","affiliation":[{"name":"School of Health Sciences Universidad Cardenal Herrera\u2010CEU, CEU Universities  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson Iv\u00e1n","family":"Agudelo Higuita","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine The University of Oklahoma Health Campus  Oklahoma City Oklahoma USA"},{"name":"Instituto de Enfermedades Infecciosas y Parasitolog\u00eda Antonio Vidal  Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"George R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"University of California\u2010Davis, Medical Center  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Chastain","sequence":"additional","affiliation":[{"name":"Department of Clinical and Administrative Pharmacy UGA College of Pharmacy  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7363-8652","authenticated-orcid":false,"given":"Andr\u00e9s F.","family":"Henao\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine University of Colorado Denver  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.05.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822002000600018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9040396"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2020.104939"},{"key":"e_1_2_9_6_1","volume-title":"StatPearls [Internet]","author":"Syed H. 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