{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:53:18Z","timestamp":1774565598901,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Although\n \n Aspergillus fumigatus<\/jats:italic>\n <\/jats:styled-content>\n remains the primary cause of invasive aspergillosis, other species\u2014including emerging cryptic ones\u2014are increasingly identified in clinical settings. These species often exhibit distinct antifungal susceptibility profiles, emphasising the importance of species\u2010level identification for effective patient management. Galactomannan, once considered specific to\n \n A. fumigatus<\/jats:italic>\n <\/jats:styled-content>\n , is now widely used for aspergillosis diagnosis regardless of species. However, its performance in detecting non\u2010\n fumigatus<\/jats:italic>\n infections remains insufficiently characterised.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To evaluate the diagnostic performance of the S\u014dna GM LFA (IMMY) in BAL samples from patients with pulmonary infections attributed to different\n Aspergillus<\/jats:italic>\n spp., including cryptic species.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We evaluated the diagnostic performance of the S\u014dna galactomannan LFA (IMMY) in bronchoalveolar lavage samples from 49 patients (15% paediatric) with probable invasive aspergillosis or COVID\u2010associated pulmonary aspergillosis, confirmed by microscopy and culture.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The etiologic agents comprised\n \n A. fumigatus<\/jats:italic>\n <\/jats:styled-content>\n sensu stricto (46.9%),\n \n A. terreus<\/jats:italic>\n <\/jats:styled-content>\n ss. (16.3%),\n \n A. flavus<\/jats:italic>\n <\/jats:styled-content>\n ss. (16.3%),\n \n A. niger<\/jats:italic>\n <\/jats:styled-content>\n ss. (6.1%),\n \n A. nidulans<\/jats:italic>\n <\/jats:styled-content>\n (4.1%) and five cryptic species (10.2%). Galactomannan index values varied across species and clinical group, with particularly low readings (0.09\u20130.31) in six cases (five involving cryptic species), suggesting reduced assay sensitivity for cryptic taxa. Paediatric samples also showed lower galactomannan levels compared to adults.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study highlights the limitations of galactomannan assays in detecting cryptic\n Aspergillus<\/jats:italic>\n infections, showing consistently low galactomannan levels in BAL. Multicenter studies are needed to validate findings and refine clinical algorithms.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/myc.70155","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:31:35Z","timestamp":1773988295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Performance of S\u014dna\n GM LFA<\/scp>\n in Pulmonary Infections Caused by Different\n Aspergillus<\/i>\n Species"],"prefix":"10.1111","volume":"69","author":[{"given":"Manuela","family":"Loaiza\u2010Oliva","sequence":"first","affiliation":[{"name":"Laboratorio de Micolog\u00eda y Diagn\u00f3stico Molecular\u2014C\u00e1tedra de Parasitolog\u00eda y Micolog\u00eda\u2014Facultad de Bioqu\u00edmica Universidad Nacional del Litoral Santa Fe Argentina"},{"name":"Instituto de Salud y Ambiente del Litoral (ISAL) \u2010 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) Santa 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