{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:17Z","timestamp":1787015777552,"version":"build-2736575974"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n Relapses occur in up to 40% of patients after prolonged courses of antifungal treatment for chronic pulmonary aspergillosis (CPA). The factors predisposing to relapse remain poorly defined.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a retrospective study of adults treated for \u2265\u20096\u2009months with oral azoles for CPA. Patients who completed antifungal therapy and were deemed not to require further treatment were included. Demographic, clinical, radiological and serological data at treatment completion were collected. CPA relapse was defined as symptomatic and radiological deterioration leading to re\u2010initiation of antifungal therapy. Cox regression and Kaplan\u2013Meier analyses were used to identify predictors of relapse and mortality.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 125 patients (56% male; mean age 61\u2009years), median treatment duration was 36\u2009months. Thirty\u2010two (26%) developed relapse; relapse rate at 1\u2009year was 16%.\n Aspergillus<\/jats:italic>\n sensitisation (specific IgE >\u20090.35\u2009IU\/mL) and elevated\n Aspergillus<\/jats:italic>\n \u2010specific IgG (>\u200940\u2009mg\/L) at treatment completion were independently associated with relapse (\n p<\/jats:italic>\n \u2009<\u20090.05). No patient with IgG <\u200940\u2009mg\/L relapsed. Underlying lung disease (COPD or prior tuberculosis), extent of radiological involvement, or treatment duration were not significantly associated with relapse or mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Aspergillus<\/jats:italic>\n sensitisation and persistently elevated\n Aspergillus<\/jats:italic>\n \u2010specific IgG at the end of antifungal therapy were independent predictors of CPA relapse. These parameters may reflect ongoing fungal airway burden and can help identify patients requiring extended or closer post\u2010treatment follow\u2010up. Underlying comorbidities were not associated with relapse risk.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/myc.70156","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:18:26Z","timestamp":1769775506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\n Aspergillus<\/i>\n <\/scp>\n Serology Predicts Relapse in Chronic Pulmonary Aspergillosis: Implications for Personalised Follow\u2010Up Strategies"],"prefix":"10.1111","volume":"69","author":[{"given":"Annabel","family":"Choyce","sequence":"first","affiliation":[{"name":"National Aspergillosis Centre, Department of Infectious Diseases Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Colombo","sequence":"additional","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre The University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrin","family":"Cyriac","sequence":"additional","affiliation":[{"name":"National Aspergillosis Centre, Department of Infectious Diseases Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrazaq","family":"Alasfour","sequence":"additional","affiliation":[{"name":"Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre The University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Kien","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Amphlett","sequence":"additional","affiliation":[{"name":"National Aspergillosis Centre, Department of Infectious Diseases Manchester University NHS Foundation Trust Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0662-1265","authenticated-orcid":false,"given":"Chris","family":"Kosmidis","sequence":"additional","affiliation":[{"name":"National Aspergillosis Centre, Department of Infectious Diseases Manchester University NHS Foundation Trust Manchester UK"},{"name":"Manchester Fungal Infection Group, Faculty of Biology, Medicine, and Health Manchester Academic Health Science Centre, University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00583-2015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2020.101041"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2021.07.030"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00057-3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.70002"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinpr.2020.100015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2014.02.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02950\u20102021"}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.70156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.70156","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.70156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:13:48Z","timestamp":1773220428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.70156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/myc.70156"],"URL":"https:\/\/doi.org\/10.1111\/myc.70156","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"assertion":[{"value":"2025-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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