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Of these, 38 isolates were obtained from bloodstream cultures, four from catheter tips and 34 from an ICU surveillance study conducted at H1. In\u00a0vitro susceptibility testing was performed according to the E.Def 7.4 EUCAST method.\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">C. parapsilosis<\/jats:styled-content>\n                        sensu stricto\n                      <\/jats:italic>\n                      isolates were genotyped using microsatellite markers, and the\n                      <jats:italic>ERG11<\/jats:italic>\n                      gene was sequenced in resistant isolates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">Candida parapsilosis<\/jats:styled-content>\n                        sensu stricto\n                      <\/jats:italic>\n                      was the most common species (65\/76 isolates; 85.5%), followed by\n                      <jats:italic>C. orthopsilosis<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098, 10.5%), and\n                      <jats:italic>C. metapsilosis<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093, 4%). Among the\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">C. parapsilosis<\/jats:styled-content>\n                        sensu stricto\n                      <\/jats:italic>\n                      isolates, 5\/65 (7.7%) were fluconazole\u2010resistant, harboured the G458S ERG11p substitution, and were detected in 2019 and 2020. Only one fluconazole\u2010resistant isolate was also voriconazole\u2010resistant; all isolates were susceptible to the remaining agents. Fluconazole\u2010resistant isolates sourced from H2 were grouped into two unrelated genotypes, and recovered from patients with haematological malignancies, tumours and central nervous system disorders. Only two patients had a history of azole exposure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This is the first report of fluconazole\u2010resistant\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. parapsilosis<\/jats:italic>\n                      <\/jats:styled-content>\n                      <jats:italic>sensu stricto<\/jats:italic>\n                      isolates harbouring the G458S ERG11p substitution in Brazil. Here reported isolates showed resistance to fluconazole alone, which is an unusual pattern among\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>C. parapsilosis<\/jats:italic>\n                      <\/jats:styled-content>\n                      <jats:italic>sensu stricto<\/jats:italic>\n                      isolates harbouring the G458S substitution.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70160","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:09:40Z","timestamp":1772960980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First Report of Fluconazole\u2010Resistant\n                    <i>Candida parapsilosis<\/i>\n                    Harbouring the\n                    <scp>G458S ERG11p<\/scp>\n                    Substitution in a Brazilian Hospital"],"prefix":"10.1111","volume":"69","author":[{"given":"Sarah Santos","family":"Gon\u00e7alves","sequence":"first","affiliation":[{"name":"Department of Pathology Federal University of Esp\u00edrito Santo  Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Bravim","family":"Maifrede","sequence":"additional","affiliation":[{"name":"Department of Pathology Federal University of Esp\u00edrito Santo  Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Y\u00e4kel","sequence":"additional","affiliation":[{"name":"Federal University of Esp\u00edrito Santo, Cassiano Ant\u00f4nio Moraes University Hospital  Vit\u00f3ria ES Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Massaroni","family":"Pe\u00e7anha","sequence":"additional","affiliation":[{"name":"Higher School of Sciences of the Brotherhood of the Holy House of Mercy of Vitoria  Vit\u00f3ria ES 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