{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:53:18Z","timestamp":1774565598019,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:00:00Z","timestamp":1772841600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Candida<\/jats:italic>\n species are common causes of nosocomial infections.\n \n Candida parapsilosis<\/jats:italic>\n <\/jats:styled-content>\n has emerged as an important pathogen\n .<\/jats:italic>\n Mortality rates associated with invasive\n \n C. parapsilosis<\/jats:italic>\n <\/jats:styled-content>\n infections range from 14.5% to 47%, with azole resistance estimated between 4% and 15%. Resistance mechanisms include mutations in\n ERG11<\/jats:italic>\n that diminish azole binding, upregulation of ergosterol biosynthesis genes due to mutations in regulatory factors like\n UPC2<\/jats:italic>\n and\n NDT80<\/jats:italic>\n , and increased efflux pump activity.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Thirty clinical strains of the\n \n C. parapsilosis<\/jats:italic>\n <\/jats:styled-content>\n complex were isolated from bloodstream cultures, biopsies and catheter tips from hospitalised patients from a major rehabilitation centre in Mexico between June 2011 and August 2016. Minimum inhibitory concentrations for fluconazole, voriconazole, itraconazole, caspofungin, micafungin, anidulafungin and amphotericin B were determined using the broth microdilution method. Whole genome sequencing was conducted using Illumina technology, with subsequent assembly and annotation. Analyses included antifungal resistance variant screening, SNP distance, average nucleotide identity and phylogenetic comparisons with publicly available genomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Most strains (96.7%, 29\/30) were identified as\n \n C. parapsilosis<\/jats:italic>\n <\/jats:styled-content>\n sensu stricto, predominantly isolated from blood. Thirty\u2010three percent of isolates showed phenotypic resistance to fluconazole. The SNP\u2010distance and maximum\u2010likelihood phylogenetic analyses revealed two distinct haplotypes and the genotype 1:\n ERG11<\/jats:italic>\n WT\/Y132F<\/jats:sup>\n ,\n CDR1<\/jats:italic>\n I1287V\/I1287V<\/jats:sup>\n and\n UPC2<\/jats:italic>\n WT\/N455D<\/jats:sup>\n was the most represented (8\/10 isolates).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n \n C. parapsilosis<\/jats:italic>\n <\/jats:styled-content>\n sensu stricto was the predominant species isolated, with a notable proportion exhibiting resistance to FLU and VOR. The Y132F variant in the\n ERG11<\/jats:italic>\n gene was present in most sequenced isolates.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/myc.70161","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:39:49Z","timestamp":1773027589000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Azole Resistance in\n \n Candida parapsilosis<\/i>\n <\/scp>\n From Patients With Burns in Mexico: A Genomic and Phylogenetic Analysis"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1935-0794","authenticated-orcid":false,"given":"Mar\u00eda de Lourdes","family":"Garc\u00eda\u2010Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda Cl\u00ednica. 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