{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T13:50:03Z","timestamp":1782222603435,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2026,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Chronic pulmonary aspergillosis (CPA) is a significant, yet often overlooked, sequela of pulmonary tuberculosis (TB), particularly in resource\u2010limited settings. Data on the seroprevalence of\n Aspergillus<\/jats:italic>\n infection in Senegal is absent, and diagnostic capacity is limited. This study aimed to determine the seroprevalence of\n Aspergillus<\/jats:italic>\n \u2010specific antibodies among patients with a history of TB in Senegal and to evaluate the performance of a Rapid Diagnostic Test (RDT) against an Enzyme\u2010Linked Immunosorbent Assay (ELISA).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A cross\u2010sectional study was conducted between April 30 to August 31, 2025 at two health centers in Senegal: Wakhinane and Yeumbeul among patients presenting with chronic respiratory symptoms. After obtaining informed consent from adult participants or from parents\/guardians for minors, a blood sample was collected from each participant and tested for Aspergillus antibodies using both a rapid diagnostic test (RDT) and an ELISA. Results were classified as positive, negative, invalid, or not tested. Prevalence and agreement between the two assays were calculated using valid results only. Demographic data were collected, and descriptive statistics with test performance analyses were conducted.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The overall seroprevalence was significantly higher by ELISA (11.9%; 38\/320) than by RDT (5.5%; 11\/201). Site\u2010specific analysis revealed disparities: Wakhinane showed higher RDT positivity (4.5% vs. 1.0%), while Yeumbeul had higher ELISA positivity (13.5% vs. 11.2%). The cohort was predominantly male (66.0%) with a median age of 30\u2009years. ROC analysis of the ELISA identified an optimal threshold that balanced sensitivity (78%) and specificity (89%).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study provided the first serological evidence of substantial\n Aspergillus<\/jats:italic>\n antibody prevalence among post\u2010TB patients in Senegal, suggesting a significant burden of undiagnosed CPA. The higher sensitivity of ELISA makes it essential for surveillance and confirmation, while the RDT's practicality offers a viable option for initial screening in peripheral clinics. These findings underscored the urgent need to integrate CPA diagnosis into routine post\u2010TB care and to strengthen fungal diagnostic capacity in West Africa.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/myc.70174","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:15:12Z","timestamp":1775906112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seroprevalence Screening of Chronic\n Aspergillus<\/i>\n Infection in a Post\u2010Tuberculosis Cohort in Senegal: A Cross\u2010Sectional Study Comparing\n ELISA<\/scp>\n and Rapid Diagnostic Tests"],"prefix":"10.1111","volume":"69","author":[{"given":"Mariama","family":"Tour\u00e9","sequence":"first","affiliation":[{"name":"Centre International de Recherche et de Formation en G\u00e9nomique Appliqu\u00e9e et de Surveillance Sanitaire (CIGASS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahima Mbaye","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Centre International de Recherche et de Formation en G\u00e9nomique Appliqu\u00e9e et de Surveillance Sanitaire (CIGASS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djiby","family":"Sow","sequence":"additional","affiliation":[{"name":"Centre International de Recherche et de Formation en G\u00e9nomique Appliqu\u00e9e et de Surveillance Sanitaire (CIGASS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou Alpha","family":"Diallo","sequence":"additional","affiliation":[{"name":"Centre International de Recherche et de Formation en G\u00e9nomique Appliqu\u00e9e et de Surveillance Sanitaire (CIGASS)"},{"name":"University Cheikh Anta Diop of Dakar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadim","family":"Diongue","sequence":"additional","affiliation":[{"name":"Centre International de Recherche et de Formation en G\u00e9nomique Appliqu\u00e9e et de Surveillance Sanitaire (CIGASS)"},{"name":"University Cheikh Anta Diop of Dakar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mame Cheikh","family":"Seck","sequence":"additional","affiliation":[{"name":"Centre International de Recherche et de Formation en G\u00e9nomique Appliqu\u00e9e et de Surveillance Sanitaire (CIGASS)"},{"name":"University Cheikh Anta Diop of Dakar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouhamadou","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Centre International de Recherche et de Formation en G\u00e9nomique Appliqu\u00e9e et de Surveillance Sanitaire (CIGASS)"},{"name":"University Cheikh Anta Diop of Dakar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daouda","family":"Ndiaye","sequence":"additional","affiliation":[{"name":"Centre International de Recherche et de Formation en G\u00e9nomique Appliqu\u00e9e et de Surveillance Sanitaire (CIGASS)"},{"name":"University Cheikh Anta Diop of Dakar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ndiaye Faly","family":"Diop","sequence":"additional","affiliation":[{"name":"Centre de Sant\u00e9 de Wakhinane Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Fortes","sequence":"additional","affiliation":[{"name":"University Cheikh Anta Diop of Dakar"},{"name":"Dalal Jamm Hospital Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Denning","sequence":"additional","affiliation":[{"name":"University of Manchester Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida Sadikh","family":"Badiane","sequence":"additional","affiliation":[{"name":"Centre International de Recherche et de Formation en G\u00e9nomique Appliqu\u00e9e et de Surveillance Sanitaire (CIGASS)"},{"name":"University Cheikh Anta Diop of Dakar"},{"name":"Dalal Jamm Hospital Dakar Senegal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00583-2015"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00140-18"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof8060576"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-020-01259-8"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00692-8"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00567-X"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.11.003"},{"issue":"1","key":"e_1_2_14_9_1","article-title":"Evaluation of a New Lateral Flow Device for the Serodiagnosis of Chronic Pulmonary Aspergillosis","volume":"14","author":"Hunter E. 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O.","year":"2018","journal-title":"Mycoses"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.simyco.2020.05.002"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008742"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9111084"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae090"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7070532"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206291"},{"key":"e_1_2_14_22_1","article-title":"Biomarkers for Invasive and Chronic Aspergillosis: Update and Future Perspectives","volume":"15","author":"Alvarez\u2010Lerma F.","year":"2025","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"issue":"1","key":"e_1_2_14_23_1","first-page":"64","article-title":"Galactomannan and \u03b2\u2010D\u2010Glucan as Adjuncts to Serology in Chronic Pulmonary Aspergillosis","volume":"30","author":"Sharma S.","year":"2024","journal-title":"Clinical Microbiology and Infection"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01810"},{"key":"e_1_2_14_25_1","volume-title":"WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action","author":"World Health Organization","year":"2022"}],"updated-by":[{"DOI":"10.1111\/myc.70202","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000}}],"container-title":["Mycoses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.70174","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/myc.70174","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/myc.70174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T13:04:08Z","timestamp":1782219848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/myc.70174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/myc.70174"],"URL":"https:\/\/doi.org\/10.1111\/myc.70174","archive":["Portico"],"relation":{},"ISSN":["0933-7407","1439-0507"],"issn-type":[{"value":"0933-7407","type":"print"},{"value":"1439-0507","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2025-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70174"}}