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Early diagnosis remains challenging with current clinical methods, yet it is essential to reduce mortality. This review examines the evolution of diagnostic strategies for mucormycosis, ranging from conventional techniques such as histopathology, culture and microscopy to advanced and emerging methods including molecular assays, serological testing, imaging and metabolomics. We also explore the ongoing transition towards integrated, rapid and non\u2010invasive diagnostic platforms that leverage novel biomarkers, portable devices and artificial intelligence. These new technologies have the potential to facilitate early diagnosis, thereby enabling early treatment and reducing the mortality rate of mucormycosis.\n                  <\/jats:p>","DOI":"10.1111\/myc.70175","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T12:37:48Z","timestamp":1776256668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnosis of Mucormycosis: Current Situation, Challenges and Future Prospects"],"prefix":"10.1111","volume":"69","author":[{"given":"Yixuan","family":"Qu","sequence":"first","affiliation":[{"name":"Rehabilitation School, Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Laboratory Medicine Research Center West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Pathogen Research West China Hospital, Sichuan University  Chengdu China"},{"name":"Center of Infectious Disease West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Qu","sequence":"additional","affiliation":[{"name":"Center of Infectious Disease West China Hospital, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2023.102557"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9040425"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.03.008"},{"issue":"11","key":"e_1_2_9_5_1","article-title":"Evaluation of Direct Examination, Culture, and Histopathology in the Diagnosis of Mucormycosis: Reiterating the Role of KOH Mount for Early Diagnosis","volume":"13","author":"Mohanty A.","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30312-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12371"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2024.2396570"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2024.107054"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0297590"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae043"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/20499361211027065"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13033"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13542"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9050592"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07373-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-021-00551-3"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2022.105388"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.983612"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2024.06.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-018-0289-y"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-10334-y"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1366472"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.223271"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.103594"},{"issue":"7","key":"e_1_2_9_26_1","article-title":"Sinonasal and Orbital Imaging Findings in COVID\u2010Associated Rhino\u2010Orbito\u2010Cerebral Mucormycosis During the Second Wave of COVID\u201019: A Retrospective Cohort Study in a Tertiary Hospital in Central India","volume":"15","author":"Shrikrishna B. 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