{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:45:18Z","timestamp":1782711918016,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Invasive pulmonary fungal infections (IPFIs) in immunocompromised children carry high morbidity and may interrupt life\u2010saving chemotherapy or haematopoietic stem cell transplantation (HSCT). Evidence on perioperative risk stratification for surgical management is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We conducted a single\u2010center retrospective cohort study of patients &lt;\u200916\u2009years with proven\/probable IPFI who underwent lung resection from 2017 to 2025, with fungal infection confirmed by pathology. Preoperative clinical variables, laboratory tests and CT features were collected. Outcomes included intraoperative blood transfusion, severe postoperative complications, 90\u2010day mortality and time to resumption of chemotherapy\/HSCT. An exploratory preoperative weighted risk score was derived and evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010three patients were included (median age 9\u2009years; 75.8% male).\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      was the most common pathogen (72.7%); 57.6% had centrally located lesions and 12.1% had multilobe involvement. Procedures were mainly lobectomy (66.7%) or wedge resection (30.3%), with VATS in 45.5%. Peripheral lesion location was associated with less intraoperative transfusion, while hemoptysis and central lesion predicted delayed resumption of chemotherapy\/HSCT; preoperative platelet count &lt;\u2009100 \u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      \/L, multilobe involvement and central location were significantly associated with severe complications. Integrating these independent findings, a 0\u20138 point composite risk score was constructed (optimism\u2010adjusted C\u2010index: 0.948). The model effectively stratified outcomes: severe complications occurred in 0% (low), 26.7% (moderate) and 75% (high) (\n                      <jats:italic>p<\/jats:italic>\n                      =\u20090.004). Among survivors, median time to resume chemotherapy\/HSCT was 18\u2009days (low) versus 35\u2009days (moderate) versus 78\u2009days (high) (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.001). All 90\u2010day deaths occurred in the high\u2010risk group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Surgery can support source control and timely oncologic treatment in selected paediatric IPFI. A simple, statistically validated preoperative score may help anticipate surgical risk and recovery time and identify a high\u2010risk subgroup with poor short\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70201","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:20:00Z","timestamp":1781785200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Surgical Outcomes and Exploratory Preoperative Risk Stratification for Invasive Pulmonary Fungal Infections in Paediatric Patients: A Single\u2010Center Retrospective Study"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-2073","authenticated-orcid":false,"given":"Gang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7719-5983","authenticated-orcid":false,"given":"Chang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taozhen","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010xi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, West China Second University Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9283-3274","authenticated-orcid":false,"given":"Xia","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, West China Second University Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof10070498"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403188"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pix046"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16452"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13763"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007\u20102117"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.01.002"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20103046.2012.01708.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14205"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2019.01.003"},{"issue":"4","key":"e_1_2_11_15_1","first-page":"193","article-title":"Surgical Treatment of Pulmonary Aspergilloma in Pediatric Patients: Report of 3 Cases","volume":"33","author":"Crehuet Gramatyka D.","year":"2020","journal-title":"Cirug\u00eda 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