{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:00:02Z","timestamp":1785236402195,"version":"3.55.0"},"reference-count":61,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100010643","name":"Cidara Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010643","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014471","name":"Mundipharma Research Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Mycoses"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The efficacy and safety of rezafungin in invasive candidiasis (IC) and candidaemia was demonstrated in the Phase 2 STRIVE and Phase 3 ReSTORE trials, and an additional cohort of patients in ReSTORE from China (ReSTORE China).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This post hoc analysis is the first time that combined data from all double\u2010blind, randomised Phase 2 and 3 rezafungin trials have been evaluated. Outcomes were comprehensively assessed across a large, diverse population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were assessed from adults with candidaemia\/IC in STRIVE (NCT02734862) and ReSTORE (NCT03667690) (including the China extension cohort) who received weekly rezafungin 400\/200\u2009mg or daily caspofungin 70\/50\u2009mg for \u2264\u20094\u2009weeks. Efficacy was assessed in the modified intent\u2010to\u2010treat population. Endpoints were Day 30 all\u2010cause mortality (ACM, primary), mycological response at Days 5 and 14 (secondary) and time to negative blood cultures (TTNBC, secondary). Treatment\u2010emergent adverse events were assessed in the safety population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 372 patients were included (rezafungin 179; caspofungin 193). Day\u201030 ACM was 20% (33\/161) for rezafungin versus 22% (39\/178) for caspofungin (weighted difference, \u22122.4% [95% confidence interval \u221211.2 to 6.4]). Day\u20105 and Day\u201014 mycological eradication rates were 73% and 70% for rezafungin versus 65% and 68% for caspofungin, respectively. Median TTNBC was shorter for rezafungin than for caspofungin (23.1 versus 36.7\u2009h, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0073). Adverse\u2010event profiles were generally similar across treatments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This pooled analysis of Phase 2 and Phase 3 data, including the China extension cohort, supports the efficacy and safety of rezafungin. Rezafungin was non\u2010inferior to caspofungin, with earlier mycological eradication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70205","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:41:15Z","timestamp":1784194875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rezafungin Versus Caspofungin in Candidaemia and Invasive Candidiasis: A Post Hoc Pooled Analysis of Phase 2 and Phase 3 Trials"],"prefix":"10.1111","volume":"69","author":[{"given":"Alex","family":"Soriano","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Hospital Cl\u00ednic de Barcelona, IDIBAPS University of Barcelona, CIBERINF  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"George R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases University of California Davis Medical Center  Sacramento California USA"},{"name":"The Department of Medical Microbiology and Immunology University of California Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[{"name":"Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD), Faculty of Medicine University of Cologne  Cologne Germany"},{"name":"Department I of Internal Medicine, Division of Infectious Diseases, Excellence Center for Medical Mycology (ECMM), Faculty of Medicine University Hospital Cologne  Cologne Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site Bonn\u2010Cologne  Cologne Germany"},{"name":"University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS K\u00f6ln)  Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bassetti","sequence":"additional","affiliation":[{"name":"University of Genoa and Policlinico San Martino IRCCS Hospital  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart Jan","family":"Kullberg","sequence":"additional","affiliation":[{"name":"Department of Medicine, Radboudumc Community for Infectious Diseases and Radboud University Medical Center  Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Honor\u00e9","sequence":"additional","affiliation":[{"name":"Department of Intensive Care CHU UCL Godinne, UCLouvain, Site Godinne  Yvoir Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herv\u00e9","family":"Dupont","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Amiens\u2010Picardie University Hospital  Amiens France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Vazquez","sequence":"additional","affiliation":[{"name":"Medical College of Georgia\/Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihui","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Antibiotics Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Antibiotics Huashan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Dickerson","sequence":"additional","affiliation":[{"name":"Clinical Development Mundipharma Research Limited  Cambridge 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