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The median age of patients with OS was 58\u2009years (IQR 39\u201364; range 18\u201383) and 55% were male. Hypertension (45%), diabetes (40%), alcohol use (40%), smoking (40%), and HIV infection (15%) were the most frequent conditions identified. Cutaneous lesions occurred in 95% of cases, and 90% of patients presented with arthralgia and edema. Multifocal OS was observed in 50% of cases, most commonly affecting the knees, fingers, and wrists. The mean time to diagnosis was 14.2\u2009months. Most patients were treated with itraconazole combined with amphotericin B; 13 required surgical intervention, including 2 amputations. The mean treatment duration was 21\u2009months. Multisystem involvement due to sporotrichosis was observed in 45% of cases, including pulmonary involvement. Mortality was 15%. Diabetes (OR\u2009=\u20094.11; 95% CI, 1.50\u201311.38;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) was independently associated with OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OS is associated with substantial morbidity and prolonged treatment. Diabetes may increase the risk of OS, while delayed diagnosis jeopardizes outcomes, underscoring the need for early management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/myc.70211","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T07:47:13Z","timestamp":1784879233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Osteoarticular Sporotrichosis in a Brazilian Endemic Setting: Associated Factors and Outcomes"],"prefix":"10.1111","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0035-6261","authenticated-orcid":false,"given":"Vanessa Caroline Randi","family":"Magalh\u00e3es","sequence":"first","affiliation":[{"name":"Department of Microbiology, Institute of Biological Sciences Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Hospital Eduardo de Menezes Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais (FHEMIG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Sampaio","family":"Moura","sequence":"additional","affiliation":[{"name":"Hospital Eduardo de Menezes Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais (FHEMIG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8819-9664","authenticated-orcid":false,"given":"F\u00e1bio","family":"do Nascimento Sales","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Biological Sciences Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2378-8649","authenticated-orcid":false,"given":"Salene Angelini","family":"Colombo","sequence":"additional","affiliation":[{"name":"Department of Preventive Veterinary Medicine, School of Veterinary Universidade Federal de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Eliane","family":"de \u00c1vila","sequence":"additional","affiliation":[{"name":"Hospital Eduardo de Menezes Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais (FHEMIG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7636-6859","authenticated-orcid":false,"given":"Jorge Miguel Schettino","family":"C\u00e9sar","sequence":"additional","affiliation":[{"name":"Hospital J\u00falia Kubitschek Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais (FHEMIG)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6851-7311","authenticated-orcid":false,"given":"Diana Manzi","family":"Viegas","sequence":"additional","affiliation":[{"name":"Hospital J\u00falia Kubitschek Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais (FHEMIG)  Belo Horizonte 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