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The diaphragm and calf muscles are most and least advanced, respectively, with respect to muscle fibre fusion and differentiation. The number and depth of subsynaptic folds increases, and perisynaptic <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chwann cells (<jats:styled-content style=\"fixed-case\">PSCs<\/jats:styled-content>) acquire a basal lamina on their outer surface. Subsynaptic folds are connected to an extensive network of tubules and beaded caveolae, reminiscent of the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> system in adult muscle. Interestingly, intercostal muscles from <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>4 <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> mice show weaker pathological involvement (that is, vacuolization of <jats:styled-content style=\"fixed-case\">PSCs<\/jats:styled-content> and perineurial cells) than those previously described by us for the diaphragm, whereas calf muscles show no pathological changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content>\u2010related alterations appear to occur only when the muscles have reached a certain developmental maturity. Moreover, glial cells, in particular <jats:styled-content style=\"fixed-case\">PSCs<\/jats:styled-content>, play an important role in <jats:styled-content style=\"fixed-case\">SMA<\/jats:styled-content> pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12064","type":"journal-article","created":{"date-parts":[[2013,5,30]],"date-time":"2013-05-30T07:26:59Z","timestamp":1369898819000},"page":"416-434","source":"Crossref","is-referenced-by-count":8,"title":["The craniosacral progression of muscle development influences the emergence of neuromuscular junction alterations in a severe murine model for spinal muscular atrophy"],"prefix":"10.1111","volume":"40","author":[{"given":"Tilman","family":"Voigt","sequence":"first","affiliation":[{"name":"Institute of Anatomy University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuja","family":"Neve","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology University of Bern  Bern 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