{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:03:07Z","timestamp":1780106587651,"version":"3.54.0"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,21]],"date-time":"2014-01-21T00:00:00Z","timestamp":1390262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Fasciculation and elongation protein zeta\u20101 (<jats:styled-content style=\"fixed-case\">FEZ<\/jats:styled-content>1) is a critical regulator of dopaminergic neurone differentiation and dopamine release. However, to date, few studies evaluating the expression patterns of <jats:styled-content style=\"fixed-case\">FEZ<\/jats:styled-content>1 in Parkinson's disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) have been reported. The aim of this study was to investigate the expression and cellular localization of <jats:styled-content style=\"fixed-case\">FEZ<\/jats:styled-content>1 in a rat model of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and to explore the role of <jats:styled-content style=\"fixed-case\">FEZ<\/jats:styled-content>1 in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Male <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>prague\u2013<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>awley rats were randomly divided into two groups: a <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> group and a sham group. A model of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> was established by injecting 6\u2010<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ydroxydopamine <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ydrobromide (6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content>) into the right medial forebrain bundle of rats. Sham\u2010lesioned rats were infused with equivalent amounts of saline and served as controls. The expression levels of <jats:styled-content style=\"fixed-case\">FEZ<\/jats:styled-content>1 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> and protein in striatum and substantia nigra were examined by real\u2010time polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) and by <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>estern blot analysis respectively. Immunohistochemistry was performed to identify the cellular localization of <jats:styled-content style=\"fixed-case\">FEZ<\/jats:styled-content>1 in sham\u2010lesioned and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>estern blot and real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> analyses demonstrated that <jats:styled-content style=\"fixed-case\">FEZ<\/jats:styled-content>1 was present in normal rat brain striatum and substantia nigra. After the 6\u2010<jats:styled-content style=\"fixed-case\">OHDA<\/jats:styled-content> injection, <jats:styled-content style=\"fixed-case\">FEZ<\/jats:styled-content>1 expression gradually increased, peaked and then decreased. Immunohistochemical detection showed a shift of <jats:styled-content style=\"fixed-case\">FEZ<\/jats:styled-content>1 expression from tyrosine hydroxylase positive neurones in sham\u2010lesioned rats to astrocytes in <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that <jats:styled-content style=\"fixed-case\">FEZ<\/jats:styled-content>1 plays a role in the astrocytic protection of dopamine neurones and in the regulation of the neuronal microenvironment during the progression of <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12077","type":"journal-article","created":{"date-parts":[[2013,7,29]],"date-time":"2013-07-29T11:51:42Z","timestamp":1375098702000},"page":"164-176","source":"Crossref","is-referenced-by-count":11,"title":["Fasciculation and elongation protein zeta\u20101 (<scp>FEZ<\/scp>1) 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