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However, for disorders such as <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>untington's disease (<jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content>), the challenges that we face are still enormous. This autosomal dominant genetic disorder leads, in part, to massive neuronal loss and severe brain atrophy which, despite the cell type used, cannot be easily repaired. And before large clinical trials are even considered, we must take a critical look at the outcomes of the pilot studies already available, not only from a clinical perspective but also by a careful assessment of what we can learn from the autopsies of <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients who have undergone transplantation. In this review, we summarize and discuss the seven transplantation pilot trials that were initiated worldwide in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> patients more than a decade ago, with a particular emphasis on the <jats:italic>post\u2010mortem<\/jats:italic> analyses of nine unique cases. Moreover, we describe a series of factors, both technical and related to patient selection, that we deem important to predict the outcome of cell grafts in <jats:styled-content style=\"fixed-case\">HD<\/jats:styled-content> therapy.<\/jats:p>","DOI":"10.1111\/nan.12104","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T06:42:36Z","timestamp":1386225756000},"page":"71-90","source":"Crossref","is-referenced-by-count":11,"title":["Review: The fate of cell grafts for the treatment of <scp>H<\/scp>untington's disease: the <i>post\u2010mortem<\/i> evidence"],"prefix":"10.1111","volume":"40","author":[{"given":"G.","family":"Cisbani","sequence":"first","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec (CHUL)  Qu\u00e9bec QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cicchetti","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec (CHUL)  Qu\u00e9bec QC 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