{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:35:29Z","timestamp":1761708929356,"version":"3.37.3"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To develop and validate a scoring method for assessing \u03b2\u2010amyloid precursor protein (<jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>) staining in cerebral white matter and to investigate the occurrence, amount and deposition pattern based on the cause of death in infants and young children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Archival cerebral tissue was examined from a total of 176 cases (0 to 3 years of age). Each of the <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content>\u2010stained sections was graded according to a simple scoring system based on the number and type of changes in eight anatomical regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Examination of the sections revealed some degree of <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> staining in 95% of the cases. The highest mean <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> scores were found in cases of head trauma, and the lowest scores were found in the cases of drowning. <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> staining, although sometimes minimal, was found in all 48 cases of and sudden infant death syndrome (<jats:styled-content style=\"fixed-case\">SIDS<\/jats:styled-content>). Patterns of <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> staining (the amount and distribution) were different in cases of head trauma, infection and <jats:styled-content style=\"fixed-case\">SIDS<\/jats:styled-content> but were similar in the <jats:styled-content style=\"fixed-case\">SIDS<\/jats:styled-content> and asphyxia groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates the use of an integrated scoring system that was developed to assess <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> staining in the brain. <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> staining was seen in a high proportion of cases, including relatively sudden deaths. The amount of <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> was significantly higher in cases of trauma than in nontraumatic deaths. However, <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> was detected within all groups. The pattern of <jats:styled-content style=\"fixed-case\">APP<\/jats:styled-content> staining was similar in infants who had died of <jats:styled-content style=\"fixed-case\">SIDS<\/jats:styled-content> and from mechanical asphyxia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12109","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T11:07:00Z","timestamp":1387278420000},"page":"385-397","source":"Crossref","is-referenced-by-count":18,"title":["\u03b2\u2010Amyloid precursor protein staining of the brain in sudden infant and early childhood death"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4702-8222","authenticated-orcid":false,"given":"Lisbeth Lund","family":"Jensen","sequence":"first","affiliation":[{"name":"Discipline of Anatomy and Pathology The University of Adelaide  Adelaide Australia"},{"name":"The Department of Pathology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Forensic 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