{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:37:21Z","timestamp":1761975441148},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2014,12]]},"abstract":"Introduction<\/jats:title>Frontotemporal lobar degeneration (FTLD<\/jats:styled-content>) is classified mainly into FTLD<\/jats:styled-content>\u2010tau and FTLD<\/jats:styled-content>\u2010TDP<\/jats:styled-content> according to the protein present within inclusion bodies. While such a classification implies only a single type of protein should be present, recent studies have demonstrated dual tau and TDP<\/jats:styled-content>\u201043 proteinopathy can occur, particularly in inherited FTLD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We therefore investigated 33 patients with FTLD<\/jats:styled-content>\u2010tau (including 9 with MAPT<\/jats:italic><\/jats:styled-content> mutation) for TDP<\/jats:styled-content>\u201043 pathological changes, and 45 patients with FTLD<\/jats:styled-content>\u2010TDP<\/jats:styled-content> (including 12 with hexanucleotide expansion in C9ORF72<\/jats:italic><\/jats:styled-content> and 12 with GRN<\/jats:italic><\/jats:styled-content> mutation), and 23 patients with motor neurone disease (3 with hexanucleotide expansion in C9ORF72<\/jats:italic><\/jats:styled-content>), for tauopathy.<\/jats:p><\/jats:sec>Results<\/jats:title>TDP<\/jats:styled-content>\u201043 pathological changes, of the kind seen in many elderly individuals with A<\/jats:styled-content>lzheimer's disease, were seen in only two FTLD<\/jats:styled-content>\u2010tau cases \u2013 a 70\u2010year\u2010old male with exon 10\u2009+\u200913 mutation in MAPT<\/jats:italic><\/jats:styled-content>, and a 73\u2010year\u2010old female with corticobasal degeneration. Such changes were considered to be secondary and probably reflective of advanced age. Conversely, there was generally only scant tau pathology, usually only within hippocampus and\/or entorhinal cortex, in most patients with FTLD<\/jats:styled-content>\u2010TDP<\/jats:styled-content> or MND<\/jats:styled-content>. The extent of tau pathology in FTLD<\/jats:styled-content>\u2010TDP<\/jats:styled-content> and MND<\/jats:styled-content>, as with amyloid \u03b2 protein, may relate to increased age and possession of A<\/jats:styled-content>polipoprotein \u03b54 allele.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We find no predilection or predisposition towards an accompanying TDP<\/jats:styled-content>\u201043 pathology in patients with FTLD<\/jats:styled-content>\u2010tau, irrespective of presence or absence of MAPT<\/jats:italic><\/jats:styled-content> mutation, or that genetic changes associated with FTLD<\/jats:styled-content>\u2010TDP<\/jats:styled-content> predispose towards excessive tauopathy. Where the two processes coexist, this is limited and probably causatively independent of each other.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12155","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T11:08:10Z","timestamp":1401188890000},"page":"844-854","source":"Crossref","is-referenced-by-count":26,"title":["No interaction between tau and TDP<\/scp>\u201043 pathologies in either frontotemporal lobar degeneration or motor neurone disease"],"prefix":"10.1111","volume":"40","author":[{"given":"Andrew C.","family":"Robinson","sequence":"first","affiliation":[{"name":"Clinical and Cognitive Sciences Research Group Institute of Brain, Behaviour and Mental Health Faculty of Medical and Human Sciences University of Manchester, Salford Royal Hospital Salford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer C.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Clinical and Cognitive Sciences Research Group Institute of Brain, Behaviour and Mental Health Faculty of Medical and Human Sciences University of Manchester, Salford Royal Hospital Salford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey","family":"Weedon","sequence":"additional","affiliation":[{"name":"Clinical and Cognitive Sciences Research Group Institute of Brain, Behaviour and Mental Health Faculty of Medical and Human Sciences University of Manchester, Salford Royal Hospital Salford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Rollinson","sequence":"additional","affiliation":[{"name":"Clinical and Cognitive Sciences Research Group Institute of Brain, Behaviour and Mental Health Faculty of Medical and Human Sciences A V Hill Building University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Pickering\u2010Brown","sequence":"additional","affiliation":[{"name":"Clinical and Cognitive Sciences Research Group Institute of Brain, Behaviour and Mental Health Faculty of Medical and Human Sciences A V Hill Building University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie S.","family":"Snowden","sequence":"additional","affiliation":[{"name":"Clinical and Cognitive Sciences Research Group Institute of Brain, Behaviour and Mental Health Faculty of Medical and Human Sciences University of Manchester, Salford Royal Hospital Salford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne S.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Clinical and Cognitive Sciences Research Group Institute of Brain, Behaviour and Mental Health Faculty of Medical and Human Sciences University of Manchester, Salford Royal Hospital Salford"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M. A.","family":"Mann","sequence":"additional","affiliation":[{"name":"Clinical and Cognitive Sciences Research Group Institute of Brain, Behaviour and Mental Health Faculty of Medical and Human Sciences University of Manchester, Salford Royal Hospital Salford"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0236-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/31508"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05017"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.82"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0765-z"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0845-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1048-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1050-0"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl289"},{"key":"e_1_2_7_14_1","first-page":"1","article-title":"C9ORF72 repeat expansions in cases with previously identified pathogenic mutations","volume":"81","author":"Blitterswijk M","year":"2013","journal-title":"Neurology"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/2051-5960-1-68"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1181-y"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21154"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0879-y"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.09.048"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0400-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31817713b5"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0702-1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1110-0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0463-2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-012-9164-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws307"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm065"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1123-8"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.4.416"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.6.1546"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318292a342"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr179"},{"key":"e_1_2_7_33_1","first-page":"96","article-title":"El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases\/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial \u2018Clinical limits of amyotrophic lateral sclerosis\u2019 workshop contributors","volume":"124","author":"Brooks BR","year":"1994","journal-title":"J Neurol Sci"},{"key":"e_1_2_7_34_1","first-page":"176","article-title":"The University of Manchester Age and Cognitive Performance Research Centre and North East Age Research Longitudinal Programmes, 1982 to 1997","volume":"26","author":"Rabbitt P","year":"1993","journal-title":"Z Gerontol"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf069"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.10.093"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e3181609361"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0189-y"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01785-2"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92724-G"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700049588"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnan.12155","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T12:35:50Z","timestamp":1696250150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nan.12155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,17]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/nan.12155"],"URL":"https:\/\/doi.org\/10.1111\/nan.12155","archive":["Portico"],"relation":{},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,17]]}}}