{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:44:00Z","timestamp":1782254640882,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Bureau","doi-asserted-by":"crossref","award":["2011-3-095"],"award-info":[{"award-number":["2011-3-095"]}],"id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Angiocentric glioma (<jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>) is a rare, slow\u2010growing tumour of the central nervous system. It is often associated with refractory epilepsy and occurs most commonly in children and young adults. We herein report nine cases of <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>, including four with atypical histological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data and clinicopathological findings of nine cases with <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content> histological features were described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All nine patients had a history of refractory epilepsy with a mean history of 4.4\u2009years and a median age of 17.6\u2009years at surgery. The <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content> lesions were located in the superficial cerebrocortical region. Histological examination of these cases revealed characteristic structural features of <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>, including bipolar spindle\u2010shaped cells with an angiocentric growth pattern. However, four cases also exhibited atypical histological features: one had astroblastoma\u2010like characteristics, two had a distinct cystic region with an onion\u2010like structure and myxoid changes, and the other one had a region involving many abnormal neurones reminiscent to ganglioglioma. All were positive for glial fibrillary acidic protein and vimentin. Eight cases were positive for epithelial membrane antigen (<jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>), with a dot\u2010like staining pattern. A diffuse <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>2\u201040 staining was visible in these cases, with two having similar staining pattern to <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>. All cases were immunonegative for <jats:styled-content style=\"fixed-case\">BRAF V<\/jats:styled-content>600<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> and isocitrate dehydrogenase\u20101 <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>132<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content> mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results demonstrate that atypical histological features can be present in <jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content>. A collection of more cases and further molecular analyses are required to confirm our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12158","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T11:08:13Z","timestamp":1401188893000},"page":"333-346","source":"Crossref","is-referenced-by-count":35,"title":["Angiocentric glioma: a report of nine new cases, including four with atypical histological features"],"prefix":"10.1111","volume":"41","author":[{"given":"Hai\u2010Chun","family":"Ni","sequence":"first","affiliation":[{"name":"Department of Neuropathology Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Department of Pathology Central Hospital of Wuhan  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neuropathology Xuanwu Hospital Capital Medical University  Beijing 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