{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:27:40Z","timestamp":1787243260848,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["MND-Net"],"award-info":[{"award-number":["MND-Net"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Deutsche Gesellschaft f\u00ef\u00bf\u00bdr Muskelkranke"},{"name":"IZKF Aachen","award":["N1-1"],"award-info":[{"award-number":["N1-1"]}]},{"name":"IZKF Aachen","award":["N5-3"],"award-info":[{"award-number":["N5-3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2015,4]]},"abstract":"\n Aim<\/jats:title>\n \n Upon denervation, skeletal muscle fibres initiate complex changes in gene expression. Many of these genes are involved in muscle fibre remodelling and atrophy. Amyotrophic lateral sclerosis (\n ALS<\/jats:styled-content>\n ) leads to progressive neurodegeneration and neurogenic muscular atrophy (NMA). Disturbed calcium homeostasis and misfolded protein aggregation both in motor neurones and muscle fibres are key elements of\n ALS<\/jats:styled-content>\n pathogenesis that are mutually interdependent. Therefore, we hypothesized that the calcium sensor\n STIM<\/jats:styled-content>\n 1 might be abnormally modified and involved in muscle fibre degeneration in\n ALS<\/jats:styled-content>\n and other types of\n NMA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We examined\n ALS<\/jats:styled-content>\n and\n NMA<\/jats:styled-content>\n patient biopsy and autopsy tissue and tissue from\n G<\/jats:styled-content>\n 93\n A SOD<\/jats:styled-content>\n 1 mice by immunohistochemistry and immunoblotting.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In normal human and mouse muscle\n STIM<\/jats:styled-content>\n 1 was found to be differentially expressed in muscle fibres of different types and to concentrate at neuromuscular junctions, compatible with its known role in calcium sensing. Denervated muscle fibres of\n sALS<\/jats:styled-content>\n and\n NMA<\/jats:styled-content>\n cases and\n SOD<\/jats:styled-content>\n 1 mice showed diffusely increased\n STIM<\/jats:styled-content>\n 1 immunoreactivity along with ubiquitinated material. In addition, distinct focal accumulations of\n STIM<\/jats:styled-content>\n 1 were observed in target structures within denervated fibres of\n sALS<\/jats:styled-content>\n and other\n NMA<\/jats:styled-content>\n as well as\n SOD<\/jats:styled-content>\n 1 mouse muscles. Large\n STIM<\/jats:styled-content>\n 1\u2010immunoreactive structures were found in\n ALS<\/jats:styled-content>\n \u20108 patient muscle harbouring the\n P<\/jats:styled-content>\n 56\n S<\/jats:styled-content>\n mutation in the\n ER<\/jats:styled-content>\n protein\n VAPB<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These findings suggest that\n STIM<\/jats:styled-content>\n 1 is involved in several ways in the reaction of muscle fibres to denervation, probably reflecting alterations in calcium homeostasis in denervated muscle fibres.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nan.12164","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T06:31:54Z","timestamp":1403591514000},"page":"304-318","source":"Crossref","is-referenced-by-count":19,"title":["Accumulation of\n STIM<\/scp>\n 1 is associated with the degenerative muscle fibre phenotype in\n ALS<\/scp>\n and other neurogenic atrophies"],"prefix":"10.1111","volume":"41","author":[{"given":"Anand","family":"Goswami","sequence":"first","affiliation":[{"name":"Institute of Neuropathology RWTH Aachen University and JARA Brain Translational Medicine Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christofer Marvin","family":"Jesse","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology RWTH Aachen University and JARA Brain Translational Medicine Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akila","family":"Chandrasekar","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology RWTH Aachen University and JARA Brain Translational Medicine Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Bushuven","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology RWTH Aachen University and JARA Brain Translational Medicine Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Tilmann","family":"Vollrath","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology RWTH Aachen University and JARA Brain Translational Medicine Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Dreser","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology RWTH Aachen University and JARA Brain Translational Medicine Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Katona","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology RWTH Aachen University and JARA Brain Translational Medicine Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordian","family":"Beyer","sequence":"additional","affiliation":[{"name":"Institute of Neuroanatomy RWTH Aachen University Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Johann","sequence":"additional","affiliation":[{"name":"Institute of Neuroanatomy RWTH Aachen University Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Feller","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital Schleswig\u2010Holstein L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Grond","sequence":"additional","affiliation":[{"name":"Department of Neurology District Hospital Siegen Siegen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Neurology District Hospital Siegen Siegen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Nikolin","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology RWTH Aachen University and JARA Brain Translational Medicine Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Troost","sequence":"additional","affiliation":[{"name":"Division of Neuropathology Department of Pathology, Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Weis","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology RWTH Aachen University and JARA Brain Translational Medicine Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-8966(93)90096-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/363266a0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/302609a0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp018933"},{"key":"e_1_2_9_6_1","first-page":"1041","article-title":"Morphological spectrum and clinical features of myopathies with tubular aggregates","volume":"28","author":"Funk F","year":"2013","journal-title":"Histol Histopathol"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.010389"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-010-9467-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0203-87"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0308-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c1dea3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00041.2007"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003209"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28773."},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0808-04.2004"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00834-6"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2008.08.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.169748"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1245-05.2005"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10597"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1123511"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450111007011250"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2990.1998.00108.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00244-6"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1066"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067122"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr559"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03160574"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.041319"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt008"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4496-09.2010"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb0302-e46a"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0856-7"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.05.055"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.006"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118947109"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806726200"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-215293"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04702"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.12.007"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8209258"},{"key":"e_1_2_9_42_1","volume-title":"Muscle Biopsy. A Practical Approach","author":"Dubowitz V","year":"2013"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00313906"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084304"},{"key":"e_1_2_9_45_1","first-page":"89","article-title":"Skeletal muscle fibre types in C57BL6J mice","volume":"21","author":"Augusto VPC","year":"2004","journal-title":"Braz J Morphol Sci"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20000915)50:6<500::AID-JEMT7>3.0.CO;2-7"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01319.x"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-005-0031-y"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609551200"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810243106"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.1070300505"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00386255"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0177(200007)218:3<438::AID-DVDY1001>3.0.CO;2-6"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00434-0"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199809000-00006"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00579.2003"},{"key":"e_1_2_9_57_1","first-page":"73","article-title":"Adaptive processes in skeletal muscle: molecular regulators and genetic influences","volume":"6","author":"Stewart CE","year":"2006","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2006.04394.x"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049862"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/191389a0"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316244"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880050915"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00531.2009"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061020"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652413804810772"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnan.12164","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:47:59Z","timestamp":1695484079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nan.12164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,4]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/nan.12164"],"URL":"https:\/\/doi.org\/10.1111\/nan.12164","archive":["Portico"],"relation":{},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,4]]}}}