{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:15:49Z","timestamp":1787015749132,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T00:00:00Z","timestamp":1430524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"La Fundaci\u00f3 Marat\u00f3 TV3 2013"},{"name":"Fundaci\u00f3n Tatiana Perez de Guzm\u00e1n el Bueno 2013"},{"name":"Spanish Ministry of Health","award":["FIS PI11\/00234"],"award-info":[{"award-number":["FIS PI11\/00234"]}]},{"name":"Spanish Ministerio de Econom\u00eda y Competividad programa","award":["PTA 2011"],"award-info":[{"award-number":["PTA 2011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2015,12]]},"abstract":"\n Aims<\/jats:title>\n \n The aims of this study were to assess the sensitivity of the\n I<\/jats:styled-content>\n nternational\n B<\/jats:styled-content>\n ehavioural\n V<\/jats:styled-content>\n ariant\n FTD C<\/jats:styled-content>\n riteria\n C<\/jats:styled-content>\n onsortium (\n FTDC<\/jats:styled-content>\n ) revised criteria of behavioural variant frontotemporal dementia (\n bvFTD<\/jats:styled-content>\n ) in a pathological cohort and to determine their predictive values in a clinical context suggestive of\n bvFTD<\/jats:styled-content>\n . In addition, the study aimed to assess the influence of the age at onset and underlying pathology in the clinicopathological correlations.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Retrospective, blinded review of the clinical and neuropathological data from the\n N<\/jats:styled-content>\n eurological\n T<\/jats:styled-content>\n issue\n B<\/jats:styled-content>\n ank of the\n B<\/jats:styled-content>\n iobank\n H<\/jats:styled-content>\n ospital\n C<\/jats:styled-content>\n linic\u2013\n IDIBAPS<\/jats:styled-content>\n ,\n B<\/jats:styled-content>\n arcelona (\n S<\/jats:styled-content>\n pain) was conducted, assessing the fulfilment of the diagnostic criteria on a case\u2010by\u2010case basis. Two separate nonexclusive cohorts were selected: Cohort 1 (\n n<\/jats:italic>\n \u2009=\u200958) subjects with pathological diagnosis of frontotemporal lobar degeneration (\n FTLD<\/jats:styled-content>\n ) and Cohort 2 (\n n<\/jats:italic>\n \u2009=\u200966) subjects with the\n premortem<\/jats:italic>\n diagnosis of\n bvFTD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n FTDC<\/jats:styled-content>\n criteria reached a sensitivity of 93% for possible and 80% for probable\n bvFTD<\/jats:styled-content>\n . Early\u2010onset cases displayed significantly more disinhibition, loss of empathy and compulsive behaviour with respect to late\u2010onset\n bvFTD<\/jats:styled-content>\n , leading to a slightly higher sensitivity of the diagnostic criteria (97%\n vs.<\/jats:italic>\n 91%). There were no differences in the diagnostic performance between tau\u2010positive and tau\u2010negative cases. In subjects clinically diagnosed as\n bvFTD<\/jats:styled-content>\n , a \u2018possible\n bvFTD<\/jats:styled-content>\n \u2019 diagnosis reached a positive predictive value for\n FTLD<\/jats:styled-content>\n pathology of 90%, irrespective of underlying proteinopathy. False\u2010positive clinical diagnoses were mainly\n A<\/jats:styled-content>\n lzheimer's disease. These cases were significantly older, had less family history of dementia and had a predominantly apathetic clinical picture.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The revised\n bvFTD<\/jats:styled-content>\n criteria present good sensitivity and positive predictive value in both early\u2010 and late\u2010onset cases and regardless of the underlying\n FTLD<\/jats:styled-content>\n pathology.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nan.12194","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T03:40:11Z","timestamp":1415590811000},"page":"882-892","source":"Crossref","is-referenced-by-count":31,"title":["Diagnostic accuracy of behavioral variant frontotemporal dementia consortium criteria (FTDC) in a clinicopathological cohort"],"prefix":"10.1111","volume":"41","author":[{"given":"Mircea","family":"Balasa","sequence":"first","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit Hospital Cl\u00ednic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Gelpi","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank of the Biobank Hospital Cl\u00ednic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idaira","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit Hospital Cl\u00ednic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Antonell","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit Hospital Cl\u00ednic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma Jesus","family":"Rey","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank of the Biobank Hospital Cl\u00ednic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol","family":"Grau\u2010Rivera","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit Hospital Cl\u00ednic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"},{"name":"Neurological Tissue Bank of the Biobank Hospital Cl\u00ednic Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Molinuevo","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit Hospital Cl\u00ednic Institut 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