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Visuo\u2010cortical and retinal abnormalities have been recorded in <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content> and may play a role in visual hallucinations. The present study aimed to investigate the lateral geniculate nucleus (<jats:styled-content style=\"fixed-case\">LGN<\/jats:styled-content>), a visual relay centre between the retina and visual cortex, to see if changes to this structure underlie visual hallucinations in <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010one [17 probable <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>, 19 control and 15 probable Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>)] cases were recruited for a functional magnetic resonance imaging study, in which patients' response to a flashing checkerboard stimulus was detected and measured in the <jats:styled-content style=\"fixed-case\">LGN<\/jats:styled-content>, before comparison across experimental groups. Additionally, <jats:italic>post mortem<\/jats:italic>\u2005<jats:styled-content style=\"fixed-case\">LGN<\/jats:styled-content> tissue was acquired for a cross\u2010sectional study using 20 (six <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>, seven control and seven <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) cases and analysed using stereology. \u03b1\u2010Synuclein, phosphorylated tau and amyloid\u2010\u03b2 pathology was also assessed in all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content> cases did not significantly differ from controls on neuroimaging, morphometry or pathology. However, a significant increase in amyloid\u2010\u03b2 pathology, a reduction in number of parvocellular neurones and magnocellular gliosis was found in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> cases compared with control and <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content> cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that the early visual system is relatively spared in <jats:styled-content style=\"fixed-case\">DLB<\/jats:styled-content>, which implies that upstream visual structures may be largely responsible for the generation of hallucinatory percepts. The significance of the degeneration of the <jats:styled-content style=\"fixed-case\">LGN<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> cases is uncertain.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12249","type":"journal-article","created":{"date-parts":[[2015,5,12]],"date-time":"2015-05-12T08:43:02Z","timestamp":1431420182000},"page":"366-376","source":"Crossref","is-referenced-by-count":29,"title":["Changes to the lateral geniculate nucleus in <scp>A<\/scp>lzheimer's disease but not dementia with <scp>L<\/scp>ewy bodies"],"prefix":"10.1111","volume":"42","author":[{"given":"Daniel","family":"Erskine","sequence":"first","affiliation":[{"name":"Institute of Neuroscience Ageing Research Laboratories  Newcastle upon Tyne UK"},{"name":"Medical Toxicology Centre Wolfson Unit of Clinical Pharmacology  Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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