{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:20:10Z","timestamp":1760955610491},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T00:00:00Z","timestamp":1458604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81301063"],"award-info":[{"award-number":["81301063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2014M552231"],"award-info":[{"award-number":["2014M552231"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of this study was to determine the functional recovery and protein regulation by transplanted induced pluripotent stem cells in a rat model of Huntington's disease (HD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a quinolinic acid\u2010induced rat model of striatal degeneration, induced pluripotent stem cells were transplanted into the ipsilateral lateral ventricle 10 days after the quinolinic acid injection. At 8 weeks after transplantation, fluorodeoxyglucose\u2010PET\/CT scan and balance\u2010beam test were performed to evaluate the functional recovery of experimental rats. In addition, immunofluorescence and protein array analysis were used to investigate the regulation of stimulated protein expression in the striatum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 8 weeks after induced pluripotent stem cell transplantation, motor function was improved in comparison with the quinolinic acid\u2010treated rats. High fluorodeoxyglucose accumulation in the injured striatum was also observed by PET\/CT scans. In addition, immunofluorescence analysis demonstrated that implanted cells migrated from the lateral ventricle into the lesioned striatum and differentiated into striatal projection neurons. Array analysis showed a significant upregulation of GFR (Glial cell line\u2010derived neurotrophic factor receptor) alpha\u20101, Adiponectin\/Acrp30, basic\u2010fibroblast growth factors, MIP\u20101 (Macrophage\u2010inflammatory protein) alpha and leptin, as well as downregulation of cytokine\u2010induced neutrophil chemoattractant\u20103 in striatum after transplantatation of induced pluripotent stem cells in comparison with the quinolinic acid \u2010treated rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings in this work indicate that transplantation of induced pluripotent stem cells is a promising therapeutic candidate for HD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12315","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T16:09:24Z","timestamp":1455034164000},"page":"521-534","source":"Crossref","is-referenced-by-count":5,"title":["Protein regulation of induced pluripotent stem cells by transplanting 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