{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:33:49Z","timestamp":1790404429081,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000858","name":"University of Sheffield","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Microinfarcts, small ischaemic foci common in ageing brain, are associated with dementia and gait dysfunction. We determined their relationship with dementia, mobility and cerebrovascular disease in an older population\u2010representative brain donor cohort. These data on microinfarcts were evaluated in relation to pathological assessments of clinically significant cerebral small vessel disease (<jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Microinfarcts were assessed in the <jats:styled-content style=\"fixed-case\">MRC<\/jats:styled-content> Cognitive Function and Ageing Study (n = 331). Nine brain areas were staged according to the number of areas affected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>36% of brains showed at least 1 microinfarct. Higher cortical microinfarct stage was associated with dementia at death (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.41, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.02; 1.96, <jats:italic>P<\/jats:italic> = 0.038), whilst cortical and subcortical microinfarct stages were associated with impaired mobility (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.36, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.05\u20131.74; <jats:italic>P<\/jats:italic> 0.018) and falls (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.96, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.11\u20133.43; <jats:italic>P<\/jats:italic> = 0.02). Adding data on microinfarcts to a definition of <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>, based on white matter lesions (<jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s), lacunes and significant arteriosclerosis, were assessed by comparing area under <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) with and without microinfarcts. <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> was significantly related to dementia status with or without inclusion of microinfarcts. Modelling potential pathological definitions of <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> to predict dementia or impaired mobility indicated optimal prediction using combined assessment of <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s, lacunes and microinfarcts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cortical (dementia) and subcortical microinfarcts (impaired mobility) are related to diverse clinical outcomes. Optimal pathological assessment of significant <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content> in brain ageing is achieved based on <jats:styled-content style=\"fixed-case\">WML<\/jats:styled-content>s, lacunes and microinfarcts and may not require subjective assessment of the extent and severity of arteriosclerosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12363","type":"journal-article","created":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T16:34:37Z","timestamp":1474734877000},"page":"409-418","source":"Crossref","is-referenced-by-count":44,"title":["Microinfarcts in an older population\u2010representative brain donor cohort (MRC CFAS): Prevalence, relation to dementia and mobility, and implications for the evaluation of cerebral Small Vessel Disease"],"prefix":"10.1111","volume":"43","author":[{"given":"P. G.","family":"Ince","sequence":"first","affiliation":[{"name":"Sheffield Institute for Translational Neuroscience University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Minett","sequence":"additional","affiliation":[{"name":"Institute of Public Health University of Cambridge Cambridge UK"},{"name":"Department of Radiology University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Forster","sequence":"additional","affiliation":[{"name":"Sheffield Institute for Translational Neuroscience University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Brayne","sequence":"additional","affiliation":[{"name":"Institute of Public Health University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. B.","family":"Wharton","sequence":"additional","affiliation":[{"name":"Sheffield Institute for Translational Neuroscience University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Medical Research Council Cognitive Function and Ageing Neuropathology Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e3182299496"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.6.749"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70307-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000579"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00395235"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000471"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.001945"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm228"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22520"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04794.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988705281872"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017215"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000180"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03589-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.09.004"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12219"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.4.479"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.595082"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.197368"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824e8e7f"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000206445.97511.ae"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/59.11.931"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828c2f52"},{"key":"e_1_2_6_25_1","first-page":"266","article-title":"Cerebral lacunae. A proposed new classification","volume":"3","author":"Poirier J","year":"1984","journal-title":"Clin Neuropathol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2012.01310.x"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnan.12363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnan.12363","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nan.12363","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:48:43Z","timestamp":1693417723000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nan.12363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,28]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/nan.12363"],"URL":"https:\/\/doi.org\/10.1111\/nan.12363","archive":["Portico"],"relation":{},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,28]]}}}