{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:22:55Z","timestamp":1792740175242,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001320","name":"Wolfson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tau is a microtubule\u2010binding protein that is important for the stability of neuronal axons. It is normally expressed within neurons and is also secreted into the brain interstitial fluid that communicates freely with cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) and, in a more restricted manner, blood via the glymphatic clearance system of the brain. In Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>), neuroaxonal degeneration results in increased release of tau from neurons. Furthermore, tau is truncated and phosphorylated, which leads to aggregation of tau in neurofibrillary tangles of the proximal axoplasm. Neuroaxonal degeneration and tangle formation are reflected by increased concentrations of total tau (T\u2010tau, measured using assays that detect most forms of tau) and phospho\u2010tau (P\u2010tau, measured using assays with antibodies specific to phosphorylated forms of tau). In <jats:styled-content style=\"fixed-case\">AD CSF<\/jats:styled-content>, both T\u2010tau and P\u2010tau concentrations are increased. In stroke and other <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> disorders with neuroaxonal injury but without tangles, T\u2010tau is selectively increased, whereas P\u2010tau concentration often stays normal. In tauopathies (diseases with both neurodegeneration and neurofibrillary tangles) other than <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> CSF<\/jats:styled-content> T\u2010tau and P\u2010tau concentrations are typically unaltered, which is a puzzling result that warrants further investigation. In the current review, I discuss the association of T\u2010tau and P\u2010tau concentrations in body fluids with neuropathological changes, imaging findings and clinical features in <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and other <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> diseases.<\/jats:p>","DOI":"10.1111\/nan.12378","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T07:02:41Z","timestamp":1483599761000},"page":"194-199","source":"Crossref","is-referenced-by-count":149,"title":["Review: Tau in biofluids \u2013 relation to pathology, imaging and clinical features"],"prefix":"10.1111","volume":"43","author":[{"given":"H.","family":"Zetterberg","sequence":"first","affiliation":[{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital M\u00f6lndal Sweden"},{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg M\u00f6lndal Sweden"},{"name":"Department of Molecular Neuroscience UCL Institute of Neurology Queen Square London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,10]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4245"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4913"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a135625"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.018"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006247"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.277061"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006446"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1993.tb09823.x"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02815140"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00070-3"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01697-9"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.9.1277"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2007-12307"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.1.95"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2009.11.012"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6883-5"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.06.009"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2009.08.020"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl269"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182563bd0"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e31823c0cf4"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.02.012"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/37.2.2492045"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151004"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199908020-00006"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000216841"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181dd4dd8"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.6455"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2012.07.027"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt163"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.367"},{"key":"e_1_2_3_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4333"},{"key":"e_1_2_3_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.1383"},{"key":"e_1_2_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.08.018"},{"key":"e_1_2_3_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076523"},{"key":"e_1_2_3_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2012.07911.x"},{"key":"e_1_2_3_38_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160448"},{"key":"e_1_2_3_39_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160633"},{"key":"e_1_2_3_40_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150962"},{"key":"e_1_2_3_41_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2013.216515"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fnan.12378","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T09:15:31Z","timestamp":1696238131000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nan.12378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/nan.12378"],"URL":"https:\/\/doi.org\/10.1111\/nan.12378","archive":["Portico"],"relation":{},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}