{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:47:07Z","timestamp":1790750827104,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/19833\u20107"],"award-info":[{"award-number":["2011\/19833\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2015\/17365\u20107"],"award-info":[{"award-number":["2015\/17365\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To perform a systematic review and meta\u2010analysis on the prevalence of transactive response DNA\u2010binding protein 43 (TDP\u201043) proteinopathy in cognitively normal older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically reviewed and performed a meta\u2010analysis on the prevalence of TDP\u201043 proteinopathy in older adults with normal cognition, evaluated by the Mini\u2010Mental State Examination or the Clinical Dementia Rating. We estimated the overall prevalence of TDP\u201043 using random\u2010effect models, and stratified by age, sex, sample size, study quality, antibody used to assess TDP\u201043 aggregates, analysed brain regions, Braak stage, Consortium to Establish a Registry for Alzheimer's Disease score, hippocampal sclerosis and geographic location.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 505 articles were identified in the systematic review, and 7 were included in the meta\u2010analysis with 1196 cognitively normal older adults. We found an overall prevalence of TDP\u201043 proteinopathy of 24%. Prevalence of TDP\u201043 proteinopathy varied widely across geographic location (North America: 37%, Asia: 29%, Europe: 14%, and Latin America: 11%). Estimated prevalence of TDP\u201043 proteinopathy also varied according to study quality (quality score &gt;7: 22% <jats:italic>vs<\/jats:italic>. quality score &lt;7: 42%), antibody used to assess TDP\u201043 proteinopathy (native: 18% <jats:italic>vs<\/jats:italic>. hyperphosphorylated: 24%) and presence of hippocampal sclerosis (without 24% <jats:italic>vs<\/jats:italic>. with hippocampal sclerosis: 48%). Other stratified analyses by age, sex, analysed brain regions, sample size and severity of AD neuropathology showed similar pooled TDP\u201043 prevalence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Different methodology to access TDP\u201043, and also differences in lifestyle and genetic factors across different populations could explain our results. Standardization of TDP\u201043 measurement, and future studies about the impact of genetic and lifestyle characteristics on the development of neurodegenerative diseases are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12430","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T23:52:48Z","timestamp":1502322768000},"page":"286-297","source":"Crossref","is-referenced-by-count":39,"title":["Prevalence of transactive response DNA\u2010binding protein 43 (TDP\u201043) proteinopathy in cognitively normal older adults: systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8170-7635","authenticated-orcid":false,"given":"C.","family":"Nascimento","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. T.","family":"Di Lorenzo Alho","sequence":"additional","affiliation":[{"name":"Department of Radiology University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"},{"name":"Instituto do C\u00e9rebro Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bazan Concei\u00e7\u00e3o Amaral","sequence":"additional","affiliation":[{"name":"Department of Pathology University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E. P.","family":"Leite","sequence":"additional","affiliation":[{"name":"Division of Geriatrics University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Nitrini","sequence":"additional","affiliation":[{"name":"Department of Neurology University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Jacob\u2010Filho","sequence":"additional","affiliation":[{"name":"Division of Geriatrics University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"Pasqualucci","sequence":"additional","affiliation":[{"name":"Department of Pathology University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R. 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