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Immunostained sections were qualitatively and semi\u2010quantitatively assessed for the appearance, distribution and intensity of staining in neurones of the dentate gyrus (DG<\/jats:styled-content>) and CA<\/jats:styled-content>4 region of the hippocampus, and the temporal cortex (Tcx).<\/jats:p><\/jats:sec>Results<\/jats:title>Lower levels of neuronal LAMP<\/jats:styled-content>\u20101 immunostaining were present in the DG<\/jats:styled-content> and Tcx in FTLD<\/jats:styled-content>\u2010tau compared to FTLD<\/jats:styled-content>\u2010TDP<\/jats:styled-content>. There was less LAMP<\/jats:styled-content>\u20101 immunostaining in FTLD<\/jats:styled-content>\u2010tau with MAPT<\/jats:styled-content><\/jats:italic> mutations, and FTLD<\/jats:styled-content>\u2010tau with Pick bodies, compared to FTLD<\/jats:styled-content>\u2010TDP<\/jats:styled-content> types A and B, and less LAMP<\/jats:styled-content>\u20101 immunostaining in FTLD<\/jats:styled-content>\u2010TDP<\/jats:styled-content> type C than in FTLD<\/jats:styled-content>\u2010TDP<\/jats:styled-content> types A and B. There was greater LAMP<\/jats:styled-content>\u20101 immunostaining in GRN<\/jats:styled-content><\/jats:italic> mutation which may reflect the underlying type A histology rather than mutation. There were no differences in neuronal LAMP<\/jats:styled-content>\u20102, CTSD<\/jats:styled-content>, EEA<\/jats:styled-content>\u20101 or LC<\/jats:styled-content>3A immunostaining between any of the five FTLD<\/jats:styled-content> histological or four genetic groups, nor between FTLD<\/jats:styled-content>\u2010TDP<\/jats:styled-content> and FTLD<\/jats:styled-content>\u2010tau.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The underlying pathological mechanism in FTLD<\/jats:styled-content>\u2010tau may lie with a relative deficiency of lysosomes, or defective vesicular transport, whereas the failure to clear TDP<\/jats:styled-content>\u201043 aggregates may lie with lysosomal dysfunction rather than a lack of available lysosomes or degradative enzymes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12500","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T07:30:41Z","timestamp":1527060641000},"page":"244-261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The role of lysosomes and autophagosomes in frontotemporal lobar degeneration"],"prefix":"10.1111","volume":"45","author":[{"given":"H. 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