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The primary deficiency of lysosome\u2010associated membrane protein\u20102 (LAMP\u20102) causes disruption of autophagy, leading to an impaired fusion of lysosomes to autophagosomes and biogenesis of lysosomes. We surveyed over 500 Danon disease patients reported in the literature from the first description to the present, in order to summarize the clinical, pathological and molecular data and treatment perspectives. An early molecular diagnosis is of crucial importance for genetic counselling and for therapeutic interventions: in male patients, the prognosis is poor due to rapid progression towards heart failure, and only heart transplantation modifies the disease course.<\/jats:p>","DOI":"10.1111\/nan.12587","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:29:53Z","timestamp":1573172993000},"page":"303-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Review: Danon disease: Review of natural history and recent advances"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5824-3118","authenticated-orcid":false,"given":"G.","family":"Cenacchi","sequence":"first","affiliation":[{"name":"Department of Biomedical and Neuromotor Sciences \u201cAlma Mater\u201d University of Bologna Bologna 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