{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:05:18Z","timestamp":1778036718416,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:00:00Z","timestamp":1588982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe four novel primary epithelial tumours of the sella with papillary architecture and Thyroid Transcription Factor 1 (TTF\u20101) expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Paraffin\u2010embedded tissue from the four cases and recurrence of patient 1 was investigated with haematoxylin\u2013eosin, special histochemical stains, immunohistochemistry with a broad panel of antibodies and next\u2010generation sequencing. The ultrastructure of one tumour was studied in tissue retrieved from paraffin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The lesions occurred in three females aged 20, 26 and 42\u00a0years and a male aged 49 years. They presented with signs and symptoms secondary to pituitary stalk compression. Preoperative neuroimaging documented mixed solid and cystic, enhancing sellar masses with suprasellar extension. Histologically, the tumours showed thin papillae lined by a single layer of cytokeratin and TTF\u20101\u2010positive cuboidal and cylindrical cells with mildly atypical nucleus. Next\u2010generation sequencing performed in three cases did not identify any mutations. The main differential diagnosis included metastasis from lung or thyroid carcinoma, extraventricular choroid plexus papilloma and sellar ependymoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We suggest the descriptive term of primary papillary epithelial tumour of the sella (PPETS) for this entity and propose that it could represent the intracranial equivalent of thyroid\u2010like low\u2010grade nasopharyngeal papillary adenocarcinoma. The cell of origin of PPETS remains undetermined although the intense and ubiquitous expression of TTF\u20101 may suggest a derivation from the infundibulum or ventricular recess. Our study expands the spectrum of sellar TTF\u20101\u2010positive tumour and challenges the view that they all derive from pituicytes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12622","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T22:10:01Z","timestamp":1587420601000},"page":"493-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Primary papillary epithelial tumour of the sella: expanding the spectrum of TTF\u20101\u2010positive sellar lesions"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3650-5572","authenticated-orcid":false,"given":"F.","family":"Roncaroli","sequence":"first","affiliation":[{"name":"Division of Neuroscience and Experimental Psychology Faculty of Biology, Medicine and Health School of Biology University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Deparment of Histopathology Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Giannini","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester USA"},{"name":"Department of Biomedical and Neuromotor Sciences (DIBINEM) Alma Mater Studiorum University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Manchester Centre for Genomic Medicine St Mary's Hospital Division of Evolution and Genomic Science University of Manchester Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"La Rosa","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Hospital and University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3475-0101","authenticated-orcid":false,"given":"J. 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