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However, there are some caveats associated with the majority of studies undertaken to date; for example, they are predominantly restricted to profiling a limited number of loci, are principally focused on DNA methylation, are performed on bulk tissue at the end stage of disease and are restricted to nominating associations rather than demonstrating causal relationships. Consequently, the downstream interpretation of these studies is limited. Owing to recent advances in state\u2010of\u2010the\u2010art cell profiling techniques, long\u2010read genomic technologies and genetic engineering methodologies, identifying cell\u2010type\u2010specific causal epigenetic changes is becoming feasible. This review seeks to provide an overview of the last 5\u00a0years of epigenomic studies of DNA modifications in Alzheimer\u2019s disease brain samples and propose new avenues for future research.<\/jats:p>","DOI":"10.1111\/nan.12650","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T10:39:10Z","timestamp":1596451150000},"page":"641-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Invited Review \u2013 A 5\u2010year update on epigenome\u2010wide association studies of DNA modifications in Alzheimer\u2019s disease: progress, practicalities and promise"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6495-2711","authenticated-orcid":false,"given":"A. 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