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Studies indicate a potential synergistic relationship between LATE\u2010NC and hyperphosphorylated tau. It is unknown if LATE\u2010NC is an independent driver of cognitive impairment or exerts its influence through synergistic relationships with tau. This cliniconeuropathological study investigated the impact of LATE\u2010NC on quantified measures of AD\u2010associated pathology and its impact on clinical measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 61 AD cases underwent neuropathological assessment for LATE\u2010NC and quantitative assessment [area covered by immunoreactivity (IR)] for early conformational tau (MC\u20101), late\u2010stage hyperphosphorylated tau (AT8) and amyloid\u2010\u03b2 in the amygdala and five neocortical regions. Clinical measures included age of disease onset, final Mini\u2010Mental State Examination (MMSE) score and rate of cognitive decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LATE\u2010NC was present in 41 AD cases (AD\/LATE\u2010NC; 67.2%). No significant differences in MC\u20101\u2010IR, AT8\u2010IR or 4G8\u2010IR were observed in any region between AD\/LATE\u2010NC and AD without LATE\u2010NC, indicating no accelerated aggregation or hyperphosphorylation of tau proteins in the AD\/LATE\u2010NC cases. Final MMSE was significantly lower in AD\/LATE\u2010NC cases and was significantly associated with LATE\u2010NC score even when controlled for the presence of both MC\u20101\u2010IR and AT8\u2010IR (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of LATE\u2010NC in AD is not associated with an increase in the burden of early or late tau or A\u03b2 pathology. LATE\u2010NC is associated with a lower final MMSE score independent of tau pathology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.12664","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T05:35:35Z","timestamp":1600839335000},"page":"722-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Concomitant LATE\u2010NC in Alzheimer's disease is not associated with increased tau or amyloid\u2010\u03b2 pathological burden"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0212-9823","authenticated-orcid":false,"given":"K. 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