{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:33:35Z","timestamp":1792215215547,"version":"4.4.0"},"reference-count":112,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI 17\u201300134"],"award-info":[{"award-number":["PI 17\u201300134"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FISPI17\/000809"],"award-info":[{"award-number":["FISPI17\/000809"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Peroxisomes play a key role in lipid metabolism, and peroxisome defects have been associated with neurodegenerative diseases such as X\u2010adrenoleukodystrophy and Alzheimer's disease. This study aims to elucidate the contribution of peroxisomes in lipid alterations of area 8 of the frontal cortex in the spectrum of TDP43\u2010proteinopathies. Cases of frontotemporal lobar degeneration\u2010TDP43 (FTLD\u2010TDP), manifested as sporadic (sFTLD\u2010TDP) or linked to mutations in various genes including expansions of the non\u2010coding region of\n                      <jats:italic>C9ORF72<\/jats:italic>\n                      (c9FTLD), and of sporadic amyotrophic lateral sclerosis (sALS) as the most common TDP43 proteinopathies, were analysed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used transcriptomics and lipidomics methods to define the steady\u2010state levels of gene expression and lipid profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results show alterations in gene expression of some components of peroxisomes and related lipid pathways in frontal cortex area 8 in sALS, sFTLD\u2010TDP and c9FTLD. Additionally, we identify a lipidomic pattern associated with the ALS\u2010FTLD\u2010TDP43 proteinopathy spectrum, notably characterised by down\u2010regulation of ether lipids and acylcarnitine among other lipid species, as well as alterations in the lipidome of each phenotype of TDP43 proteinopathy, which reveals commonalities and disease\u2010dependent differences in lipid composition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Globally, lipid alterations in the human frontal cortex of the ALS\u2010FTLD\u2010TDP43 proteinopathy spectrum, which involve cell membrane composition and signalling, vulnerability against cellular stress and possible glucose metabolism, are partly related to peroxisome impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.12681","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T06:56:50Z","timestamp":1608274610000},"page":"544-563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Lipid alterations in human frontal cortex in ALS\u2010FTLD\u2010TDP43 proteinopathy spectrum are partly related to peroxisome impairment"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-0338","authenticated-orcid":false,"given":"Pol","family":"Andr\u00e9s\u2010Benito","sequence":"first","affiliation":[{"name":"Neuropathology Bellvitge University Hospital\u2010Bellvitge Biomedical Research Institute (IDIBELL Hospitalet de Llobregat, Barcelona Spain"},{"name":"Department of Pathology and Experimental Therapeutics University of Barcelona Barcelona Spain"},{"name":"CIBERNED (Network Centre of Biomedical Research of Neurodegenerative Diseases Institute of Health Carlos III Ministry of Economy and Competitiveness Madrid Spain"},{"name":"International Initiative for Treatment and Research Initiative to Cure ALS (TRICALS Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-4187","authenticated-orcid":false,"given":"Ellen","family":"Gelpi","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank of the Biobanc\u2010Hospital Cl\u00ednic\u2010Institut d'Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS Barcelona Spain"},{"name":"Institute of Neurology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5577-6162","authenticated-orcid":false,"given":"Mariona","family":"Jov\u00e9","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Lleida \u2010 Lleida Biomedical Research Institute (UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5937-7070","authenticated-orcid":false,"given":"Natalia","family":"Mota\u2010Martorell","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Lleida \u2010 Lleida Biomedical Research Institute (UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-1634","authenticated-orcid":false,"given":"\u00c8lia","family":"Obis","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Lleida \u2010 Lleida Biomedical Research Institute (UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-0299","authenticated-orcid":false,"given":"Manuel","family":"Portero\u2010Otin","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Lleida \u2010 Lleida Biomedical Research Institute (UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f2nica","family":"Povedano","sequence":"additional","affiliation":[{"name":"International Initiative for Treatment and Research Initiative to Cure ALS (TRICALS Utrecht The Netherlands"},{"name":"Functional Unit of Amyotrophic Lateral Sclerosis (UFELA Service of Neurology Bellvitge University Hospital Hospitalet de Llobregat Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9606-0600","authenticated-orcid":false,"given":"Aurora","family":"Pujol","sequence":"additional","affiliation":[{"name":"Catalan Institution for Research and Advanced Studies (ICREA Barcelona Spain"},{"name":"Neurometabolic Diseases Laboratory Bellvitge Biomedical Research Institute Hospital Duran i Reynals Hospitalet de Llobregat, Barcelona Spain"},{"name":"Center for Biomedical Research on Rare Diseases (CIBERER Institute of Health Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-6107","authenticated-orcid":false,"given":"Reinald","family":"Pamplona","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine University of Lleida \u2010 Lleida Biomedical Research Institute (UdL\u2010IRBLleida Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-8754","authenticated-orcid":false,"given":"Isidro","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Neuropathology Bellvitge University Hospital\u2010Bellvitge Biomedical Research Institute (IDIBELL Hospitalet de Llobregat, Barcelona Spain"},{"name":"Department of Pathology and Experimental Therapeutics University of Barcelona Barcelona Spain"},{"name":"CIBERNED (Network Centre of Biomedical Research of Neurodegenerative Diseases Institute of Health Carlos III Ministry of Economy and Competitiveness Madrid Spain"},{"name":"International Initiative for Treatment and Research Initiative to Cure ALS (TRICALS Utrecht The Netherlands"},{"name":"Institute of Neurosciences University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1966.46.2.323"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.29.18481"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.74.082803.133329"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.03.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-6889-5_2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3700"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.01.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-018-1722-5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00033.2016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.09.024"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.12.005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-011-1061-y"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.01.054"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-6889-5_1"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a013243"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2015.00083"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100616-060608"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.13"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2011.12.014"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3159"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201412066"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1998.tb00139.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707103370215"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-005-7059-y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2006.09.010"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20702"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20535"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2010.01.001"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2013.09.009"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.92.463"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.11.015"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.03.013"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-6889-5_3"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12788"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-018-9761-9"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2009-1199"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-8"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101608"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0836-9"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111661"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1504890112"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00459"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S171490"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205014666170505094549"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X16666180828100002"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20413"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172911.39167.b6"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.033"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e31802c3e7d"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10561-008-9077-0"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-014-1287-y"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385157-4.00585-6"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0845-8"},{"key":"e_1_2_7_55_1","first-page":"209","volume-title":"Neuropathology of Neurodegenerative Diseases: A Practical Guide","author":"Hortobagyi T","year":"2015"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1238-y"},{"key":"e_1_2_7_57_1","first-page":"703","article-title":"Lipid profile in human frontal cortex is sustained throughout healthy adult life span to decay at advanced ages","volume":"73","author":"Cabr\u00e9 R","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-017-9961-2"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.01.018"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2015.05.008"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2009.0902"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2017.02.001"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2009.12.002"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac403181c"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52263-w"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2011.335"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-018-1367-3"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.04.010"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-017-1744-3"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1089"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10050186"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.101082"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.09.027"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-013-8614-4"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150336"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-2627-5_24"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2014.01.014"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R005959"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2010.00391.x"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7827(85)90011-6"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.2741\/2258"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02635576"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39619-X"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-3084(71)90031-4"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(78)90373-1"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2005.01.009"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14011310"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.04.003"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16787"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)40184-1"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2690281"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2012.09.009"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3420057"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R700019-JLR200"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9010068"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2015.03.060"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-017-0423-5"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2011.06.008"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2012.05.008"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2010.07.003"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161215"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800095-JLR200"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.12.010"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97949"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4157(98)00019-7"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.169"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.107"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1242"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2011.00119"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.08.027"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.02.022"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165720"},{"key":"e_1_2_7_113_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-1087"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12681","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nan.12681","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12681","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T07:39:02Z","timestamp":1693553942000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nan.12681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,12]]},"references-count":112,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/nan.12681"],"URL":"https:\/\/doi.org\/10.1111\/nan.12681","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/NAN.12681\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12681\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12681\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12681\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12681\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12681\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,12]]},"assertion":[{"value":"2020-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}