{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:01:20Z","timestamp":1782939680638,"version":"3.54.5"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG037491\u201011"],"award-info":[{"award-number":["R01 AG037491\u201011"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the burden of transactive response DNA\u2010binding protein of 43\u00a0kDa (TDP\u201043) inclusions in a unique cohort of old\u2010age patients with genetic frontotemporal lobar degeneration (gFTLD\u2010TDP) and compare these patients with sporadic old\u2010age individuals with TDP\u201043, either in the presence of Alzheimer's disease (AD\u2010TDP) or in isolation (pure\u2010TDP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The brain bank at Mayo Clinic\u2010Jacksonville was searched for cases \u226575\u00a0years old at death with TDP\u201043 extending into middle frontal cortex. Cases were split into the following groups: (1) gFTLD\u2010TDP (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015) with progranulin (\n                      <jats:italic>GRN<\/jats:italic>\n                      )\/\n                      <jats:italic>C9ORF72<\/jats:italic>\n                      mutations; (2) AD\u2010TDP (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010)\u2014cases with median Braak neurofibrillary tangle (NFT) stage VI, Thal phase V; (3) pure\u2010TDP (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a010)\u2014cases with median Braak NFT stage I, Thal phase I. Clinical data were abstracted; TDP\u201043 burden was calculated using digital pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Amnestic Alzheimer's dementia was the clinical diagnosis in \u226550% patients in each group. The distribution of TDP\u201043 burden in gFTLD\u2010TDP and AD\u2010TDP, but not pure\u2010TDP, was limbic\u2010predominant targeting CA1 and subiculum. Patients with gFTLD\u2010TDP had higher burden in entorhinal cortex compared to AD\u2010TDP. TDP\u201043 burden in middle frontal cortex did not differ between the three groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In old age it is challenging to clinically and pathologically differentiate gFTLD\u2010TDP from AD\u2010TDP and pure\u2010TDP\u201043 based on burden. Like AD\u2010TDP, old age gFTLD\u2010TDP have a limbic predominant TDP\u201043 distribution. The finding that amnestic Alzheimer's dementia was the most common clinical diagnosis regardless of group suggests that TDP\u201043 directly and indirectly targets limbic regions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.12727","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T23:04:46Z","timestamp":1620601486000},"page":"1050-1059","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Old age genetically confirmed frontotemporal lobar degeneration with TDP\u201043 has limbic predominant TDP\u201043 deposition"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-5430","authenticated-orcid":false,"given":"Marina","family":"Buciuc","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer 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