{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:48:53Z","timestamp":1790498933018,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["FP7\u2010241622"],"award-info":[{"award-number":["FP7\u2010241622"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004895","name":"European Social Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CPII16\/00016"],"award-info":[{"award-number":["CPII16\/00016"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PFIS FI12\/00457"],"award-info":[{"award-number":["PFIS FI12\/00457"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI20\/00759"],"award-info":[{"award-number":["FIS PI20\/00759"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI17\/00916"],"award-info":[{"award-number":["FIS PI17\/00916"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI14\/00410"],"award-info":[{"award-number":["FIS PI14\/00410"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI19\/0108"],"award-info":[{"award-number":["FIS PI19\/0108"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI14\/00328"],"award-info":[{"award-number":["FIS PI14\/00328"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI13\/00584"],"award-info":[{"award-number":["FIS PI13\/00584"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI17\/00134"],"award-info":[{"award-number":["FIS PI17\/00134"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["FIS PI14\/01115"],"award-info":[{"award-number":["FIS PI14\/01115"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      Mitochondrial dysfunction and inflammation are at the core of axonal degeneration in several multifactorial neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease, and Parkinson's disease. The transcriptional coregulator RIP140\/NRIP1 (receptor\u2010interacting protein 140) modulates these functions in liver and adipose tissue, but its role in the nervous system remains unexplored. Here, we investigated the impact of RIP140 in the\n                      <jats:italic>Abcd1<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>\u2212<\/jats:italic>\n                      <\/jats:sup>\n                      mouse model of X\u2010linked adrenoleukodystrophy (X\u2010ALD), a genetic model of chronic axonopathy involving the convergence of redox imbalance, bioenergetic failure, and chronic inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We provide evidence that RIP140 is modulated through a redox\u2010dependent mechanism driven by very long\u2010chain fatty acids (VLCFAs), the levels of which are increased in X\u2010ALD. Genetic inactivation of RIP140 prevented mitochondrial depletion and dysfunction, bioenergetic failure, inflammatory dysregulation, axonal degeneration and associated locomotor disabilities in vivo in X\u2010ALD mouse models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Together, these findings show that aberrant overactivation of RIP140 promotes neurodegeneration in X\u2010ALD, underscoring its potential as a therapeutic target for X\u2010ALD and other neurodegenerative disorders that present with metabolic and inflammatory dyshomeostasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.12747","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T13:21:35Z","timestamp":1625750495000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6478-3815","authenticated-orcid":false,"given":"Pablo","family":"Ranea\u2010Robles","sequence":"first","affiliation":[{"name":"Neurometabolic Diseases Laboratory Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"CIBERER U759, Center for Biomedical Research on Rare Diseases ISCIII  Madrid Spain"},{"name":"Department of Genetics and Genomic Sciences, Icahn Institute for Data Science and Genomic Technology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Galino","sequence":"additional","affiliation":[{"name":"Neurometabolic Diseases Laboratory Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"CIBERER U759, Center for Biomedical Research on Rare Diseases ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llu\u00eds","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Institut Municipal d'Investigacions M\u00e8diques Hospital del Mar  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agatha","family":"Schl\u00fcter","sequence":"additional","affiliation":[{"name":"Neurometabolic Diseases Laboratory Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"CIBERER U759, Center for Biomedical Research on Rare Diseases ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Neurometabolic Diseases Laboratory Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"CIBERER U759, Center for Biomedical Research on Rare Diseases ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel Ylagan","family":"Calingasan","sequence":"additional","affiliation":[{"name":"Feil Family Brain and Mind Research Institute Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Villarroya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biomedicine and Institut de Biomedicina University of Barcelona  Barcelona Catalonia Spain"},{"name":"Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n CIBER  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Naud\u00ed","sequence":"additional","affiliation":[{"name":"Experimental Medicine Department University of Lleida\u2010IRBLleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinald","family":"Pamplona","sequence":"additional","affiliation":[{"name":"Experimental Medicine Department University of Lleida\u2010IRBLleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-8754","authenticated-orcid":false,"given":"Isidre","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Experimental Therapeutics University of Barcelona  Barcelona Spain"},{"name":"Center for Biomedical Research on Neurodegenerative Diseases (CIBERNED) ISCIII  Madrid Spain"},{"name":"Institute of Neurosciences University of Barcelona  Barcelona Spain"},{"name":"Neuropathology Bellvitge University Hospital\u2010Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Flint","family":"Beal","sequence":"additional","affiliation":[{"name":"Feil Family Brain and Mind Research Institute Weill Cornell Medical College  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-0299","authenticated-orcid":false,"given":"Manuel","family":"Portero\u2010Ot\u00edn","sequence":"additional","affiliation":[{"name":"Experimental Medicine Department University of Lleida\u2010IRBLleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Fourcade","sequence":"additional","affiliation":[{"name":"Neurometabolic Diseases Laboratory Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"CIBERER U759, Center for Biomedical Research on Rare Diseases ISCIII  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9606-0600","authenticated-orcid":false,"given":"Aurora","family":"Pujol","sequence":"additional","affiliation":[{"name":"Neurometabolic Diseases Laboratory Bellvitge Biomedical Research Institute (IDIBELL)  Barcelona Spain"},{"name":"CIBERER U759, Center for Biomedical Research on Rare Diseases ISCIII  Madrid Spain"},{"name":"Catalan Institution of Research and Advanced Studies (ICREA)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.05.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/JME-16-0156"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22383"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0213"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401013101"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26040"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.08.004"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2238"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-121699"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-006-9051-1"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2016.08.003"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2011.00731.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.1585"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/361726a0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199901)45:1<100::AID-ART16>3.0.CO;2-U"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-7-51"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2010.00390.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt361"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05292"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.01.177"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12869"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn085"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3877"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22363"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt186"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt143"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.20"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr536"},{"issue":"24","key":"e_1_2_11_30_1","first-page":"6861","article-title":"Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy","volume":"24","author":"Ruiz M","year":"2015","journal-title":"Hum Mol Genet"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708604"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy127"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.0769"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171242"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700554"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006283222607"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.12044"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25085"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21391"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt645"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25303"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00735-2"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi384"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.5.499"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/82183"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90736.2008"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108655"},{"key":"e_1_2_11_48_1","first-page":"2997","article-title":"Functional overlap between ABCD1 (ALD) and ABCD2 (ALDR) transporters: a therapeutic target for X\u2010adrenoleukodystrophy","volume":"13","author":"Pujol A","year":"2004","journal-title":"HumMolGenet"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws370"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1655-9"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-007-0288-4"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1378-8"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.05.041"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0008-5"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu157"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005062"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1159\/000433539"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3469"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70016-5"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/724904"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.12.045"},{"issue":"1","key":"e_1_2_11_62_1","first-page":"37","article-title":"RIP140 is associated with subclinical inflammation in type 2 diabetic patients","volume":"121","author":"Xue J","year":"2013","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4544"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.12.002"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.11.033"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.6.4228"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2540"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-0619"},{"key":"e_1_2_11_69_1","first-page":"109","article-title":"The genetic landscape of X\u2010linked adrenoleukodystrophy: inheritance, mutations, modifier genes, and diagnosis","volume":"8","author":"Wiesinger C","year":"2015","journal-title":"Appl Clin Genet"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2010.00392.x"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nan.12747","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:07:09Z","timestamp":1692817629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nan.12747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/nan.12747"],"URL":"https:\/\/doi.org\/10.1111\/nan.12747","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/NAN.12747\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12747\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12747\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12747\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12747\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12747\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]},"assertion":[{"value":"2020-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12747"}}