{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:59:07Z","timestamp":1787900347764,"version":"build-2784847793"},"reference-count":142,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:00:00Z","timestamp":1628121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014667","name":"British Neuropathological Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013128","name":"Multiple System Atrophy Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018889","name":"Multiple System Atrophy Coalition","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018889","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Neurodegenerative movement disorders (NMDs) are age\u2010dependent disorders that are characterised by the degeneration and loss of neurons, typically accompanied by pathological accumulation of different protein aggregates in the brain, which lead to motor symptoms. NMDs include Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, and Huntington's disease, among others. Epigenetic modifications are responsible for functional gene regulation during development, adult life and ageing and have progressively been implicated in complex diseases such as cancer and more recently in neurodegenerative diseases, such as NMDs. DNA methylation is by far the most widely studied epigenetic modification and consists of the reversible addition of a methyl group to the DNA without changing the DNA sequence. Although this research field is still in its infancy in relation to NMDs, an increasing number of studies point towards a role for DNA methylation in disease processes. This review addresses recent advances in epigenetic and epigenomic research in NMDs, with a focus on human brain DNA methylation studies. We discuss the current understanding of the DNA methylation changes underlying these disorders, the potential for use of these DNA modifications in peripheral tissues as biomarkers in early disease detection, classification and progression as well as a promising role in future disease management and therapy.<\/jats:p>","DOI":"10.1111\/nan.12757","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T22:53:39Z","timestamp":1627426419000},"page":"897-909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Neurodegenerative movement disorders: An epigenetics perspective and promise for the future"],"prefix":"10.1111","volume":"47","author":[{"given":"Megha","family":"Murthy","sequence":"first","affiliation":[{"name":"Queen Square Brain Bank for Neurological Disorders UCL Queen Square Institute of Neurology  London UK"},{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Yung","family":"Cheng","sequence":"additional","affiliation":[{"name":"Queen Square Brain Bank for Neurological Disorders UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice L.","family":"Holton","sequence":"additional","affiliation":[{"name":"Queen Square Brain Bank for Neurological Disorders UCL Queen Square Institute of Neurology  London UK"},{"name":"Department of Clinical and Movement Neurosciences UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9090-7690","authenticated-orcid":false,"given":"Concei\u00e7\u00e3o","family":"Bettencourt","sequence":"additional","affiliation":[{"name":"Queen Square Brain Bank for Neurological Disorders UCL Queen Square Institute of Neurology  London UK"},{"name":"Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0240-z"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2020-0011"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781315382715"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5254.1423"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24656"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-35"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63233-3.00017-8"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2007.05.008"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.2741\/4654"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2018.04.008"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.12.017"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2010.08.008"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-53889-1_19"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcn.12634"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2015.05.002"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-011-0210-2"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-4525-4_22"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1590-9"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1685"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes10020172"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237905"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2014.16.3\/mmorris"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(88)90122-2"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.10.3195"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds035"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.947102"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.11.031"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.101535.109"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063443"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14148"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0408-0"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1001316"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt482"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54879"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708044114"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.01.038"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2015.03.002"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.110"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.03.022"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2014.08.021"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002154"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1433-y"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151222604"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2017.33"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00039"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1086\/524110"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0871-x"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau6190"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0357-6"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12650"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61393-3"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009258"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13186"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.04.078"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30287-X"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104946"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30230-7"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C110.212589"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2018.12.005"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-017-0007-3"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6119-09.2010"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015522"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26073"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-017-0285-z"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25784"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134087"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells7100150"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.10.004"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-011-0308-3"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.25865"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci7070074"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000342"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00281"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.5257"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.214"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-020-00582-4"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-018-0211-3"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0690-y"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-020-01960-1"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90219-0"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00504-7"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-2012-11056"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-02074-0"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00950-5"},{"key":"e_1_2_13_88_1","article-title":"MOBP and HIP1 in multiple system atrophy: new alpha\u2010synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis","author":"Bettencourt C","year":"2020","journal-title":"Neuropathol Appl Neurobiol"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00908-7"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-00946-1"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30157-6"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2015"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70042-0"},{"key":"e_1_2_13_95_1","article-title":"Genetics of progressive supranuclear palsy: a review","author":"Wen Y","year":"2020","journal-title":"J Parkinsons Dis"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.859"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0267-3"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26820"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05325-y"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1576-7"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.10.025"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405193302001"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1093-168"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00017"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20190"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801893-4.00001-8"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.10.060"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(89)90168-0"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.3.185"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101005"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18255-5"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.07.001"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-013-8219-0"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu561"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw076"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm346"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.11.1771"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074956"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014821"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r115"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.016"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa334"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1177\/2633105520942221"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100859"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27506"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00335"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2019.1588682"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004211"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-017-0466-5"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-016-0497-x"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15065-7"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0621-5"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00655"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz189"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12037"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature26000"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0766-2"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21134718"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-021-00837-7"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19103199"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.064865.117"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1566-2"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.08.019"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12757","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nan.12757","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T12:57:47Z","timestamp":1693227467000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nan.12757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,5]]},"references-count":142,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/nan.12757"],"URL":"https:\/\/doi.org\/10.1111\/nan.12757","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/NAN.12757\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,5]]},"assertion":[{"value":"2021-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}