{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:59:56Z","timestamp":1792112396529,"version":"4.4.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T00:00:00Z","timestamp":1630800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["602102"],"award-info":[{"award-number":["602102"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","award":["279062"],"award-info":[{"award-number":["279062"]}],"id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","award":["MR\/L016311\/1"],"award-info":[{"award-number":["MR\/L016311\/1"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS065838"],"award-info":[{"award-number":["R01 NS065838"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54 EB020403"],"award-info":[{"award-number":["U54 EB020403"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS097719"],"award-info":[{"award-number":["R01 NS097719"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004631","name":"Fondazione Antonio Carlo Monzino","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004631","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000295","name":"Epilepsy Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012738","name":"Katy Baggott Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2022,2]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n The causes of distinct patterns of reduced cortical thickness in the common human epilepsies, detectable on neuroimaging and with important clinical consequences, are unknown. We investigated the underlying mechanisms of cortical thinning using a systems\u2010level analysis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Imaging\u2010based cortical structural maps from a large\u2010scale epilepsy neuroimaging study were overlaid with highly spatially resolved human brain gene expression data from the Allen Human Brain Atlas. Cell\u2010type deconvolution, differential expression analysis and cell\u2010type enrichment analyses were used to identify differences in cell\u2010type distribution. These differences were followed up in post\u2010mortem brain tissue from humans with epilepsy using Iba1 immunolabelling. Furthermore, to investigate a causal effect in cortical thinning, cell\u2010type\u2010specific depletion was used in a murine model of acquired epilepsy.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n We identified elevated fractions of microglia and endothelial cells in regions of reduced cortical thickness. Differentially expressed genes showed enrichment for microglial markers and, in particular, activated microglial states. Analysis of post\u2010mortem brain tissue from humans with epilepsy confirmed excess activated microglia. In the murine model, transient depletion of activated microglia during the early phase of the disease development prevented cortical thinning and neuronal cell loss in the temporal cortex. Although the development of chronic seizures was unaffected, the epileptic mice with early depletion of activated microglia did not develop deficits in a non\u2010spatial memory test seen in epileptic mice not depleted of microglia.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n These convergent data strongly implicate activated microglia in cortical thinning, representing a new dimension for concern and disease modification in the epilepsies, potentially distinct from seizure control.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nan.12758","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T18:10:26Z","timestamp":1628878226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["A systems\u2010level analysis highlights microglial activation as a modifying factor in common epilepsies"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9265-2393","authenticated-orcid":false,"given":"Andre","family":"Altmann","sequence":"first","affiliation":[{"name":"Centre for Medical Image Computing University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Ryten","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Di Nunzio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ravizza","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Tolomeo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina H.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyma","family":"Somani","sequence":"additional","affiliation":[{"name":"Division of Neuropathology UCL Queen Square Institute of Neurology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Bacigaluppi","sequence":"additional","affiliation":[{"name":"Department of Neurology San Raffaele Scientific Institute and Vita Salute San Raffaele University Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Iori","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Micotti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7481-5198","authenticated-orcid":false,"given":"Rossella","family":"Di Sapia","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica","family":"Cerovic","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Palma","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Ruffolo","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan A.","family":"Bot\u00eda","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology London UK"},{"name":"Departamento de Ingenier\u00eda de la Informaci\u00f3n y las Comunicaciones Universidad de Murcia Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Absil","sequence":"additional","affiliation":[{"name":"Department of Radiology H\u00f4pital Erasme, Universite Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saud","family":"Alhusaini","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Therapeutics Royal College of Surgeons in Ireland Dublin Ireland"},{"name":"Neurology Department Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina K. M.","family":"Alvim","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Auvinen","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Kuopio University Kuopio Finland"},{"name":"Institute of Clinical Medicine, Neurology University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Bargallo","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Image Core Facility IDIBAPS Barcelona Spain"},{"name":"Centre de Diagnostic Per la Imatge (CDIC) Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Bartolini","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit Children's Hospital A. Meyer\u2010University of Florence Florence Italy"},{"name":"Neurology Unit USL Centro Toscana, Nuovo Ospedale Santo Stefano Prato Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3205-4631","authenticated-orcid":false,"given":"Benjamin","family":"Bender","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe P. G.","family":"Bergo","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauana","family":"Bernardes","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Bernasconi","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris C.","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Lab, Montreal Neurological Institute and Hospital McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Blackmon","sequence":"additional","affiliation":[{"name":"Psychiatry and Psychology Mayo Clinic Jacksonville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eugenia","family":"Caligiuri","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Department of Medical and Surgical Sciences University \u201cMagna Gr\u00e6cia\u201d of Catanzaro Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Calvo","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Image Core Facility IDIBAPS Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Carlson","sequence":"additional","affiliation":[{"name":"Comprehensive Epilepsy Center, Department of Neurology New York University School of Medicine New York New York USA"},{"name":"Department of Neurology Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J. A.","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpiero L.","family":"Cavalleri","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Therapeutics Royal College of Surgeons in Ireland Dublin Ireland"},{"name":"FutureNeuro Research Centre RCSI Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cendes","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Chen","sequence":"additional","affiliation":[{"name":"Cognitive Science Department Xiamen University Xiamen China"},{"name":"Fujian Key Laboratory of the Brain\u2010like Intelligent Systems Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cherubini","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Department of Medical and Surgical Sciences University \u201cMagna Gr\u00e6cia\u201d of Catanzaro Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Concha","sequence":"additional","affiliation":[{"name":"Instituto de Neurobiolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico Quer\u00e9taro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"David","sequence":"additional","affiliation":[{"name":"Department of Radiology H\u00f4pital Erasme, Universite Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Delanty","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Therapeutics Royal College of Surgeons in Ireland Dublin Ireland"},{"name":"FutureNeuro Research Centre RCSI Dublin Ireland"},{"name":"Division of Neurology Beaumont Hospital Dublin 9 Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Depondt","sequence":"additional","affiliation":[{"name":"Department of Neurology H\u00f4pital Erasme, Universite Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orrin","family":"Devinsky","sequence":"additional","affiliation":[{"name":"Department of Neurology, Langone School of Medicine New York University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin P.","family":"Doherty","sequence":"additional","affiliation":[{"name":"FutureNeuro Research Centre RCSI Dublin Ireland"},{"name":"School of Medicine Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Domin","sequence":"additional","affiliation":[{"name":"Functional Imaging Unit, Institute of Diagnostic Radiology and Neuroradiology University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels K.","family":"Focke","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"Department of Clinical Neurophysiology University Medicine G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonya","family":"Foley","sequence":"additional","affiliation":[{"name":"The Welsh Epilepsy Unit, Department of Neurology University Hospital of Wales Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Franca","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gambardella","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Department of Medical and Surgical Sciences University \u201cMagna Gr\u00e6cia\u201d of Catanzaro Catanzaro Italy"},{"name":"Institute of Neurology University \u201cMagna Gr\u00e6cia\u201d Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Guerrini","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit Children's Hospital A. Meyer\u2010University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Hamandi","sequence":"additional","affiliation":[{"name":"The Welsh Epilepsy Unit, Department of Neurology University Hospital of Wales Cardiff UK"},{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology Cardiff University Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derrek P.","family":"Hibar","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry","family":"Isaev","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme D.","family":"Jackson","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Austin Campus Melbourne Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neda","family":"Jahanshad","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reetta","family":"K\u00e4lvi\u00e4inen","sequence":"additional","affiliation":[{"name":"Epilepsy Center, Department of Neurology Kuopio University Kuopio Finland"},{"name":"Institute of Clinical Medicine, Neurology University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon S.","family":"Keller","sequence":"additional","affiliation":[{"name":"Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kochunov","sequence":"additional","affiliation":[{"name":"Maryland Psychiatric Research Center, Department of Psychiatry University of Maryland School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raviteja","family":"Kotikalapudi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"Functional Imaging Unit, Institute of Diagnostic Radiology and Neuroradiology University Medicine Greifswald Greifswald Germany"},{"name":"Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena A.","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Austin Campus Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Kuzniecky","sequence":"additional","affiliation":[{"name":"Department of Neurology Zucker Hofstra School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kwan","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School Monash University Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Labate","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Department of Medical and Surgical Sciences University \u201cMagna Gr\u00e6cia\u201d of Catanzaro Catanzaro Italy"},{"name":"Institute of Neurology University \u201cMagna Gr\u00e6cia\u201d Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soenke","family":"Langner","sequence":"additional","affiliation":[{"name":"Functional Imaging Unit, Institute of Diagnostic Radiology and Neuroradiology University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Lenge","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit Children's Hospital A. Meyer\u2010University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Neuroimaging of Epilepsy Laboratory, Montreal Neurological Institute and Hospital McGill University Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Mascalchi","sequence":"additional","affiliation":[{"name":"\u201cMario Serio\u201d Department of Experimental and Clinical Biomedical Sciences University of Florence Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Meletti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia, NOCSE Hospital Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia E.","family":"Morita\u2010Sherman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas Brazil"},{"name":"Cleveland Clinic Neurological Institute Cleveland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence J.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School Monash University Melbourne Victoria Australia"},{"name":"The Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C.","family":"Pariente","sequence":"additional","affiliation":[{"name":"Magnetic Resonance Image Core Facility IDIBAPS Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience King's College London London UK"},{"name":"Department of Neurology King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Rodriguez\u2010Cruces","sequence":"additional","affiliation":[{"name":"Multimodal Imaging and Connectome Analysis Lab, Montreal Neurological Institute and Hospital McGill University Montreal Quebec Canada"},{"name":"Instituto de Neurobiolog\u00eda Universidad Nacional Aut\u00f3noma de M\u00e9xico Quer\u00e9taro Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rummel","sequence":"additional","affiliation":[{"name":"Support Center for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taavi","family":"Saavalainen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, Neurology University of Eastern Finland Kuopio Finland"},{"name":"Medical Imaging Unit Central Finland Central Hospital Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira K.","family":"Semmelroch","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health Austin Campus Melbourne Victoria Australia"},{"name":"Florey Department of Neuroscience and Mental Health The University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4730-5322","authenticated-orcid":false,"given":"Mariasavina","family":"Severino","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Department of Head and Neck and Neurosciences Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Striano","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Muscular Diseases Unit, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thesen","sequence":"additional","affiliation":[{"name":"Comprehensive Epilepsy Center, Department of Neurology New York University School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhys H.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institute of Translational and Clinical Research Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Tondelli","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Neurological Institute Cleveland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Tortora","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Department of Head and Neck and Neurosciences Istituto Giannina Gaslini Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Elisabetta","family":"Vaudano","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Metabolic, and Neural Science University of Modena and Reggio Emilia, NOCSE Hospital Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Vivash","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Central Clinical School Monash University Melbourne Victoria Australia"},{"name":"Melbourne Brain Centre, Department of Medicine University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"von Podewils","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medicine Greifswald Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Ulm and Universit\u00e4ts\u2010 and Rehabilitationskliniken Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute of Experimental Epileptology and Cognition Research University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Wiest","sequence":"additional","affiliation":[{"name":"Support Center for Advanced Neuroimaging (SCAN), University Institute for Diagnostic and Interventional Neuroradiology, Inselspital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa L.","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Campinas Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Electrical Engineering University of Maryland, Baltimore County Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cognitive Science Department Xiamen University Xiamen China"},{"name":"Fujian Key Laboratory of the Brain\u2010like Intelligent Systems Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ENIGMA\u2010Epilepsy Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costin","family":"Leu","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Lerner Research Institute Cleveland Clinic Cleveland Ohio USA"},{"name":"Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge Massachusetts USA"},{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreja","family":"Avbersek","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research Broad Institute of Harvard and MIT Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EpiPGX Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7712-2629","authenticated-orcid":false,"given":"Maria","family":"Thom","sequence":"additional","affiliation":[{"name":"Division of Neuropathology UCL Queen Square Institute of Neurology London UK"},{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Whelan","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Therapeutics Royal College of Surgeons in Ireland Dublin Ireland"},{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Thompson","sequence":"additional","affiliation":[{"name":"Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute University of Southern California Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie R.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Multimodal Imaging Laboratory University of California San Diego San Diego California USA"},{"name":"Department of Psychiatry University of California San Diego San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Vezzani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Istituto di Ricerche Farmacologiche Mario Negri IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay M.","family":"Sisodiya","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Queen Square Institute of Neurology London UK"},{"name":"Chalfont Centre for Epilepsy Bucks UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.05.014"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70171-1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07524-z"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a022392"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-312314"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12779"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13965"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx341"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000790"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.07.018"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.192"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.030"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10110"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4205"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11405"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4171"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02773.x"},{"issue":"11","key":"e_1_2_11_19_1","first-page":"3130","article-title":"n\u20103 docosapentaenoic acid\u2010derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis","volume":"141","author":"Frigerio F","year":"2018","journal-title":"Brain"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2834"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.12.007"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.032"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00323"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba2619"},{"key":"e_1_2_11_25_1","first-page":"e2420v1","article-title":"tmod: an R package for general and multivariate enrichment analysis","volume":"4","author":"Weiner J","year":"2016","journal-title":"PeerJ"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.11.008"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0242-x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06008-4"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.09.039"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-015-0203-5"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4222"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1246949"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.02.040"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.22095"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1097-7"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2006.01.002"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2004.00636.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.08.012"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02547.x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.06.003"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy276"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12011"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.04.007"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16904"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.06.028"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03566-5"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004176"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1703784"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.09.004"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.0941"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13457"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2018.1515917"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nan.12758","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:07:24Z","timestamp":1692817644000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nan.12758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,5]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/nan.12758"],"URL":"https:\/\/doi.org\/10.1111\/nan.12758","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/470518","asserted-by":"object"}]},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,5]]},"assertion":[{"value":"2021-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12758"}}