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Both cell populations contribute to tumour aggressiveness and immune evasion through the actions of various signalling molecules. The scavenger and pattern recognition receptor CD204 is associated with a pro\u2010tumourigenic phenotype of TAMs and has a negative prognostic value. Our objective was to investigate the possible interaction between TAMs and dedifferentiated glioblastoma cells and characterise the myeloid phenotype of CD204\u2010enriched glioblastomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Double immunohistochemistry and cell counting was performed on eight glioblastoma samples to estimate the expression and interaction level between dedifferentiated\/stem\u2010like tumour cells and TAMs. Using the NanoString technology, myeloid transcriptome profiling was performed on 46 glioblastomas, which had been selected based on their protein expression levels of CD204 and ionised calcium\u2010binding adaptor molecule\u20101 (IBA1). The results were validated by immunohistochemistry and\n                      <jats:italic>in silico<\/jats:italic>\n                      gene expression analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      TAMs especially CD204\n                      <jats:sup>+<\/jats:sup>\n                      TAMs accumulated in perivascular and perinecrotic niches in close proximity to podoplanin\n                      <jats:sup>+<\/jats:sup>\n                      glioblastoma cells. Gene profiling revealed that CD204\u2010enriched glioblastoma has a unique signature with upregulation of genes related to hypoxia, angiogenesis and invasion, including interleukin\u20106. The gene signature favoured a poor prognosis in patients with glioblastoma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is the first study to characterise the role of CD204 in the myeloid microenvironment of glioblastoma. Our results support the unfavourable prognostic impact of CD204 and suggest that CD204 and interleukin\u20106 could serve as targets for re\u2010education of TAMs and potentiation of current anti\u2010glioma therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.12772","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T03:04:47Z","timestamp":1635476687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Tumour\u2010associated CD204\n                    <sup>+<\/sup>\n                    microglia\/macrophages accumulate in perivascular and perinecrotic niches and correlate with an interleukin\u20106\u2010enriched inflammatory profile in glioblastoma"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0105-2940","authenticated-orcid":false,"given":"Mia 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