{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:16:38Z","timestamp":1789110998497,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T00:00:00Z","timestamp":1639094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008539","name":"CurePSP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016608","name":"Rainwater Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Accumulating evidence suggests that patients with frontotemporal lobar degeneration (FTLD) can have pathologic accumulation of multiple proteins, including tau and TDP\u201043. This study aimed to determine the frequency and characteristics of concurrent tau pathology in FTLD with TDP\u201043 pathology (FTLD\u2010TDP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study included 146 autopsy\u2010confirmed cases of FTLD\u2010TDP and 55 cases of FTLD\u2010TDP with motor neuron disease (FTLD\u2010MND). Sections from the basal forebrain were screened for tau pathology with phosphorylated\u2010tau immunohistochemistry. For cases with tau pathology on the screening section, additional brain sections were studied to establish a diagnosis. Genetic analysis of\n                      <jats:italic>C9orf72<\/jats:italic>\n                      ,\n                      <jats:italic>GRN<\/jats:italic>\n                      and\n                      <jats:italic>MAPT<\/jats:italic>\n                      was performed on select cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found 72 cases (36%) with primary age\u2010related tauopathy (PART), 85 (42%) with ageing\u2010related tau astrogliopathy (ARTAG), 45 (22%) with argyrophilic grain disease (AGD) and 2 cases (1%) with corticobasal degeneration (CBD). Patients with ARTAG or AGD were significantly older than those without these comorbidities. One of the patients with FTLD\u2010TDP and CBD had\n                      <jats:italic>C9orf72<\/jats:italic>\n                      mutation and relatively mild tau pathology, consistent with incidental CBD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The coexistence of TDP\u201043 and tau pathologies was relatively common, particularly PART and ARTAG. Although rare, patients with FTLD can have multiple neurodegenerative proteinopathies. The absence of TDP\u201043\u2010positive astrocytic plaques may suggest that CBD and FTLD\u2010TDP were independent disease processes in the two patients with both tau and TDP\u201043 pathologies. It remains to be determined if mixed cases represent a unique disease process or two concurrent disease processes in an individual.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.12778","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T20:03:02Z","timestamp":1637870582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Concurrent tau pathologies in frontotemporal lobar degeneration with TDP\u201043 pathology"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-9700","authenticated-orcid":false,"given":"Shunsuke","family":"Koga","sequence":"first","affiliation":[{"name":"Department of Neuroscience Mayo Clinic  Jacksonville Florida 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