{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:05Z","timestamp":1772160785415,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["INT19\/00016"],"award-info":[{"award-number":["INT19\/00016"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/1330"],"award-info":[{"award-number":["PI20\/1330"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01896"],"award-info":[{"award-number":["PI17\/01896"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015496","name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015496","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001673","name":"Fondation J\u00e9r\u00f4me Lejeune","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1111\/nan.12781","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T05:56:35Z","timestamp":1637906195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Neuropathology of a patient with Alzheimer disease treated with low doses of verubecestat"],"prefix":"10.1111","volume":"48","author":[{"given":"Marta","family":"Querol\u2010Vilaseca","sequence":"first","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5366-7832","authenticated-orcid":false,"given":"S\u00f2nia","family":"Sirisi","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Molina\u2010Porcel","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank of the Biobanc\u2010Hospital Cl\u00ednic\u2010IDIBAPS  Barcelona Spain"},{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic de Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriu","family":"Molina","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"Pegueroles","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Ferrer\u2010Ravent\u00f3s","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Nu\u00f1ez\u2010Llaves","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oriol","family":"Dols\u2010Icardo","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mircea","family":"Balasa","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank of the Biobanc\u2010Hospital Cl\u00ednic\u2010IDIBAPS  Barcelona Spain"},{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic de Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Florencia","family":"Iulita","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Blesa","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Belbin","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6824-6942","authenticated-orcid":false,"given":"Jordi","family":"Clarimon","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Fortea","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2948-4187","authenticated-orcid":false,"given":"Ellen","family":"Gelpi","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank of the Biobanc\u2010Hospital Cl\u00ednic\u2010IDIBAPS  Barcelona Spain"},{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic de Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"},{"name":"Institute of Neurology Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"S\u00e1nchez\u2010Valle","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank of the Biobanc\u2010Hospital Cl\u00ednic\u2010IDIBAPS  Barcelona Spain"},{"name":"Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Cl\u00ednic de Barcelona\u2010IDIBAPS University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Lle\u00f3","sequence":"additional","affiliation":[{"name":"Memory Unit, Department of Neurology, Institut d'Investigacions Biom\u00e8diques Sant Pau \u2010 Hospital de Sant Pau Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-019-00613-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00307"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-141959"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706441"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M511018200"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.1721"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23270"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.09579"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1558-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812840"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1813435"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1804-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-017-0093-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074069"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1152-3"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nan.12781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T06:10:47Z","timestamp":1693116647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nan.12781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/nan.12781"],"URL":"https:\/\/doi.org\/10.1111\/nan.12781","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/NAN.12781\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12781\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12781\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12781\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12781\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,7]]},"assertion":[{"value":"2021-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12781"}}