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By contrast, nonhuman primates (NHPs) share a close neurobiology with humans in virtually all aspects relevant to developing a translational AD model. The present investigation used African green monkeys (AGMs) to refine an inducible NHP model of AD based on the administration of amyloid\u2010beta oligomers (A\u03b2Os), a key upstream initiator of AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A\u03b2Os or vehicle were repeatedly delivered over 4\u2009weeks to age\u2010matched young adult AGMs by intracerebroventricular (ICV) or intrathecal (IT) injections. Induction of AD\u2010like pathology was assessed in subregions of the medial temporal lobe (MTL) by quantitative immunohistochemistry (IHC) using the AT8 antibody to detect hyperphosphorylated tau. Hippocampal volume was measured by magnetic resonance imaging (MRI) scans prior to, and after, intrathecal injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IT administration of A\u03b2Os in young adult AGMs revealed an elevation of tau phosphorylation in the MTL cortical memory circuit compared with controls. The largest increases were detected in the entorhinal cortex that persisted for at least 12\u2009weeks after dosing. MRI scans showed a reduction in hippocampal volume following A\u03b2O injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Repeated IT delivery of A\u03b2Os in young adult AGMs led to an accelerated AD\u2010like neuropathology in MTL, similar to human AD, supporting the value of this translational model to de\u2010risk the clinical trial of diagnostic and therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.12800","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T07:22:30Z","timestamp":1644823350000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Intrathecal amyloid\u2010beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease"],"prefix":"10.1111","volume":"48","author":[{"given":"Dustin R.","family":"Wakeman","sequence":"first","affiliation":[{"name":"Virscio Inc.  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