{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:03Z","timestamp":1787015883339,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T00:00:00Z","timestamp":1649548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004726","name":"Ministry of Health, British Columbia","doi-asserted-by":"publisher","award":["202005_ONCO_ALAGGIO"],"award-info":[{"award-number":["202005_ONCO_ALAGGIO"]}],"id":[{"id":"10.13039\/501100004726","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Astroblastomas are neuroepithelial tumours defined by the presence of\n                    <jats:italic>MN1<\/jats:italic>\n                    rearrangement and are typically located in the cerebral hemispheres. Rare cases of astroblastoma\u2010like tumours carrying an\n                    <jats:italic>EWSR1\u2010BEND2<\/jats:italic>\n                    fusion have been recently described in the brain stem and spinal cord. We report a paediatric case of neuroepithelial astroblastoma\u2010like tumour occurring in the spine and carrying a novel\n                    <jats:italic>MAMLD1\u2010BEND2<\/jats:italic>\n                    fusion. We believe that our case aligns with the rare astroblastoma\u2010like tumours with\n                    <jats:italic>EWSR1\u2010BEND2<\/jats:italic>\n                    fusion, in terms of non\u2010hemispheric location, pathology, methylation profile and activation of\n                    <jats:italic>BEND2<\/jats:italic>\n                    transcription. Whether they may represent a distinct entity or a variant of\n                    <jats:italic>MN1<\/jats:italic>\n                    \u2010altered astroblastoma is not clear.\n                  <\/jats:p>","DOI":"10.1111\/nan.12814","type":"journal-article","created":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T23:13:29Z","timestamp":1647558809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Paediatric astroblastoma\u2010like neuroepithelial tumour of the spinal cord with a\n                    <i>MAMLD1\u2010BEND2<\/i>\n                    rearrangement"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1477-8855","authenticated-orcid":false,"given":"Sabrina","family":"Rossi","sequence":"first","affiliation":[{"name":"Pathology Unit, Department of Laboratories, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Barresi","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Laboratories, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Stefania","family":"Colafati","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Imaging Department, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Giovannoni","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Laboratories, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Miele","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Alesi","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics, Translational Cytogenomics Research Unit, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Cacchione","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Diomedi\u2010Camassei","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Laboratories, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Macari","sequence":"additional","affiliation":[{"name":"GenomeUp s.r.l Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manila","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Department of Radiology, Oncology and Anatomic Pathology University La Sapienza  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Carboni","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Imaging Department, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Carai","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Mastronuzzi","sequence":"additional","affiliation":[{"name":"Department of Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Giangaspero","sequence":"additional","affiliation":[{"name":"Department of Radiology, Oncology and Anatomic Pathology University La Sapienza  Rome Italy"},{"name":"IRCCS Neuromed  Isernia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Gessi","sequence":"additional","affiliation":[{"name":"Neuropathology Unit, Pathology Division, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universit\u00e0 Cattolica S. Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Alaggio","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Laboratories, Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12565"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381\u2010004\u20101055\u20107"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.9.SPINE161302"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010019\u20100689\u20103"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12561"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12593"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10014\u2010021\u201000412\u20103"},{"key":"e_1_2_7_10_1","first-page":"16","article-title":"Molecular clarification of brainstem astroblastoma with EWSR1\u2010BEND2 fusion in a 38\u2010year\u2010old man","volume":"2","author":"Smith\u2010Cohn MA","year":"2021","journal-title":"Free Neuropathology"},{"issue":"2","key":"e_1_2_7_11_1","article-title":"Cervicomedullary Astroblastoma with EWSR1\u2010BEND2 Fusion: Expanding the Molecular Heterogeneity of Astroblastomas and the HGNET\u2010MN1 Methylation Class Family","volume":"34","author":"Velazquez Vega J","year":"2021","journal-title":"Mod Pathol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010021\u201002388\u2010y"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12659"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010021\u201000783\u20100"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.213314.113"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.01.015"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201019389\u20109"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nan.12814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.12814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:01:02Z","timestamp":1692835262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nan.12814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,10]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/nan.12814"],"URL":"https:\/\/doi.org\/10.1111\/nan.12814","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/NAN.12814\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12814\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12814\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12814\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/NAN.12814\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,10]]},"assertion":[{"value":"2021-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12814"}}