{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T06:59:16Z","timestamp":1787900356005,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003136","name":"Edmond J. Safra Philanthropic Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003136","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study is to clarify whether there is a difference in amyloid\u2010beta burden between gyral crests (GCs) and sulcal depths (SDs) in different neurodegenerative proteinopathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analysed the burden and distribution of amyloid\u2010beta deposition in post\u2010mortem brain samples from 138 autopsies, including Alzheimer's disease (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930), Down's syndrome (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911), Lewy body disease (LBD;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953), multiple system atrophy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098) and progressive supranuclear palsy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936). We applied quantitative amyloid\u2010beta burden analysis to compare amyloid\u2010beta deposition in both GCs and SDs. We also evaluated the prevalence of amyloid\u2010beta plaques in both regions in samples exhibiting high or low amounts of amyloid\u2010beta pathology.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Amyloid\u2010beta burden was evaluated in 67 and 84 samples of the frontal and temporal cortices, respectively. We did not find significant differences in the amyloid\u2010beta burden between GCs and SDs in these regions in any examined disease. In addition, amyloid\u2010beta plaques were almost evenly distributed in both regions in cases with low amounts of amyloid\u2010beta pathology. Females in the LBD group showed significantly higher amyloid\u2010beta burden than males (temporal cortex,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Furthermore, only one LBD case showed SD\u2010predominant deposition associated with the coarse\u2010grained plaques.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We have shown that amyloid\u2010beta is almost evenly distributed in both GCs and SDs in the frontal and temporal lobes from the early stage, in diverse neurodegenerative diseases. Sex may contribute to differences in the amyloid\u2010beta burden. The coarse\u2010grained plaque may show SD\u2010predominant neuritic tau deposition that must be carefully distinguished from chronic traumatic encephalopathy\u2010related SD tau pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.12869","type":"journal-article","created":{"date-parts":[[2022,12,17]],"date-time":"2022-12-17T03:29:06Z","timestamp":1671247746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lack of difference between amyloid\u2010beta burden at gyral crests and sulcal depths in diverse neurodegenerative diseases"],"prefix":"10.1111","volume":"49","author":[{"given":"Shojiro","family":"Ichimata","sequence":"first","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Disease University of Toronto  Toronto ON Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto ON Canada"},{"name":"Department of Legal Medicine, Faculty of Medicine University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ain","family":"Kim","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Disease University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-1768","authenticated-orcid":false,"given":"Naoki","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Faculty of Medicine University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-5511","authenticated-orcid":false,"given":"Gabor G.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Tanz Centre for Research in Neurodegenerative Disease University of Toronto  Toronto ON Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto ON Canada"},{"name":"Edmond J. 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