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Synapses degenerate early during the pathogenesis of AD. We studied whether the \ud835\udefdCTF accumulates in synapses in SAD, autosomal dominant AD (ADAD) and Down syndrome (DS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used array tomography to determine APP at synapses in human AD tissue. We measured \ud835\udefdCTF, A\ud835\udefd40, A\ud835\udefd42 and phosphorylated tau181 (p\u2010tau181) concentrations in brain homogenates and synaptosomes of frontal and temporal cortex of SAD, ADAD, DS and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>APP colocalised with pre\u2010 and post\u2010synaptic markers in human AD brains. APP \ud835\udefdCTF was enriched in AD synaptosomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrate that \ud835\udefdCTF accumulates in synapses in SAD, ADAD and DS. This finding might suggest a role for \ud835\udefdCTF in synapse degeneration. Therapies aimed at mitigating \ud835\udefdCTF accumulation could be potentially beneficial in AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.12879","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T22:06:19Z","timestamp":1674770779000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Amyloid precursor protein \ud835\udefdCTF accumulates in synapses in sporadic and genetic forms of Alzheimer's disease"],"prefix":"10.1111","volume":"49","author":[{"given":"Paula","family":"Ferrer\u2010Ravent\u00f3s","sequence":"first","affiliation":[{"name":"Department of Neurology, Sant Pau Memory Unit, Sant Pau Biomedical Research Institute Hospital de la Santa Creu i Sant Pau, Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)  Madrid 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