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The underlying neurobiological mechanisms are not known. Oxytocin (OXT) is involved in the regulation of emotion, social cognition and metabolism, and our previous work showed that the OXT system is affected early in HD. The aim of the study was to investigate the potential causal relationship between the selective expression of mutant huntingtin (mHTT) in OXT neurons and the development of non\u2010motor features and neuropathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To express mHTT only in OXT neurons, we used a novel flex\u2010switch adeno\u2010associated viral vector design to selectively express either mHTT or wild\u2010type HTT in the paraventricular nucleus of the hypothalamus using OXT\u2010Cre\u2010recombinase mice. We also performed a mirror experiment to selectively delete mHTT in OXT neurons using the BACHD mouse model. Mice underwent a battery of behavioural tests to assess psychiatric and social behaviours 3\u00a0months post\u2010injection or at 2\u2009months of age, respectively. Post\u2010mortem analyses were performed to assess the effects on the OXT system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Our results show that selective expression of mHTT in OXT neurons was associated with the formation of mHTT inclusions and a 26% reduction of OXT\u2010immunopositive neurons as well as increased anxiety\u2010like behaviours compared with uninjected mice. However, selective deletion of mHTT from OXT neurons alone was not sufficient to alter the metabolic and psychiatric phenotype of the BACHD mice at this early time point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results indicate that mHTT expression can exert cell\u2010autonomous toxic effects on OXT neurons without affecting the non\u2010motor phenotype at early time points in mice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.12891","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T02:58:43Z","timestamp":1676257123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of mutant huntingtin in oxytocin neurons on non\u2010motor features of Huntington's 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