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In patients that had received CuATSM, p62\u2010immunoreactive astrocytes were observed in the motor cortex and reduced Iba1 density was found in the spinal cord. However, no significant difference in measures of astrocytic activity and SOD1 immunoreactivity was found with CuATSM treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These findings, in this first postmortem investigation of patients with ALS in CuATSM trials, demonstrate that in contrast to that seen in preclinical models of disease, CuATSM does not significantly alleviate neuronal pathology or astrogliosis in patients with ALS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.12919","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T03:12:06Z","timestamp":1686798726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Treatment with the copper compound CuATSM has no significant effect on motor neuronal pathology in patients with ALS"],"prefix":"10.1111","volume":"49","author":[{"given":"Yue","family":"Yang","sequence":"first","affiliation":[{"name":"Brain and Mind Centre University of Sydney  Sydney New South Wales Australia"},{"name":"Faculty of Medicine and Health, School of Medical Sciences University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Rowe","sequence":"additional","affiliation":[{"name":"Macquarie University Centre for Motor Neuron Disease Research, Faculty of Medicine, Health and Human Sciences Macquarie University  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"McCann","sequence":"additional","affiliation":[{"name":"Neuroscience Research Australia  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-3218","authenticated-orcid":false,"given":"Claire 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