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In addition, this approach provides complementary insights to conventional case\u2013control studies, which tend to be more representative of a younger clinical cohort. The Cognitive Function and Ageing Study (CFAS) is a longitudinal study of cognitive impairment and frailty in the general United Kingdom population. In this review, we provide an overview of the major findings from CFAS, alongside other studies, which have demonstrated a high prevalence of pathology in the ageing brain, particularly Alzheimer's disease neuropathological change and vascular pathology. Increasing burdens of these pathologies are the major correlates of dementia, especially neurofibrillary tangles, but there is substantial overlap in pathology between those with and without dementia, particularly at intermediate burdens of pathology and also at the oldest ages. Furthermore, additional pathologies such as limbic\u2010predominant age\u2010related TDP\u201043 encephalopathy, ageing\u2010related tau astrogliopathy and primary age\u2010related tauopathies contribute to late\u2010life dementia. Findings from ageing population\u2010representative studies have implications for the understanding of dementia pathology in the community. The high prevalence of pathology and variable relationship to dementia status has implications for disease definition and indicate a role for modulating factors on cognitive outcome. The complexity of late\u2010life dementia, with mixed pathologies, indicates a need for a better understanding of these processes across the life\u2010course to direct the best research for reducing risk in later life of avoidable clinical dementia syndromes.<\/jats:p>","DOI":"10.1111\/nan.12923","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T06:13:33Z","timestamp":1689660813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Insights into the pathological basis of dementia from population\u2010based neuropathology studies"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2785-333X","authenticated-orcid":false,"given":"Stephen B.","family":"Wharton","sequence":"first","affiliation":[{"name":"Sheffield Institute for Translational Neuroscience University of Sheffield  Sheffield 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