{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T23:57:21Z","timestamp":1774483041694,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018001","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de lutte contre les Cancers et les leuc\u00e9mies de l'Enfant et de l'Adolescent","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006331","name":"Cancerop\u00f4le PACA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012094","name":"F\u00e9d\u00e9ration Enfants Cancers Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2024,12]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n \n FGFR<\/jats:italic>\n \u2010fused central nervous system (CNS) tumours are rare and are usually within the glioneuronal and neuronal tumours or the paediatric\u2010type diffuse low\u2010grade glioma spectrum. Among this spectrum,\n FGFR2<\/jats:italic>\n fusion has been documented in tumours classified by DNA\u2010methylation profiling as polymorphous low\u2010grade neuroepithelial tumours of the young (PLNTY), a recently described tumour type. However,\n FGFR2<\/jats:italic>\n fusions have also been reported in glioneuronal tumours, highlighting the overlapping diagnostic criteria and challenges.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We investigated the\n FGFR2<\/jats:italic>\n fusion landscape in a French national series of tumours sent to the RENOCLIP\u2010LOC network. We comprehensively analysed histology, radiology and molecular data including DNA\u2010methylation profiling for 16\n FGFR2<\/jats:italic>\n \u2010fused glioneuronal tumours.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Most tumours were located in the temporal or parietal lobe with a median age at diagnosis of 7\u00a0years [1\u201344]. Epilepsy was the most frequent symptom. Five patients had tumour progression or recurrence with a median progression\u2010free survival of 22.6\u00a0months. Histological phenotypes corresponding to PLNTY, GG, MVNT or unclassified tumours were recorded. Epigenetic profiling could not properly distinguish epigenetic clusters related to the GG and PLNTY methylation classes among\n FGFR2<\/jats:italic>\n \u2010fused glioneuronal tumours. However, a neuroradiological review identified strikingly distinct neuroradiological patterns.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n While delineating tumour types among the\n FGFR2<\/jats:italic>\n \u2010fused glioneuronal tumour spectrum, by histopathology or DNA\u2010methylation profiling, remains challenging, neuroimaging data revealed two distinct patterns that could correlate to PLNTY and ganglioglioma. However, more series including extensive histo\u2010radio\u2010molecular data are needed to confirm this hypothesis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/nan.13014","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T01:07:03Z","timestamp":1731028023000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phenotypic and epigenetic heterogeneity in\n FGFR2<\/i>\n \u2010fused glial and glioneuronal tumours"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5924-3555","authenticated-orcid":false,"given":"Alice","family":"M\u00e9tais","sequence":"first","affiliation":[{"name":"Service de Neuropathologie, GHU Paris Psychiatrie et Neurosciences Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266 Paris 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France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude\u2010Alain","family":"Maurage","sequence":"additional","affiliation":[{"name":"Department of Pathology Lille University Hospital Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Uro\u2010Coste","sequence":"additional","affiliation":[{"name":"Department of Pathology Toulouse University Hospital Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Meyronet","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Est, D\u00e9partement de Neuropathologie, Hospices Civils de Lyon Bron France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Rigau","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gui de Chauliac Hospital Montpellier University Medical Center Montpellier 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