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PCA\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      presents with visual and spatial dysfunction attributed to occipito\u2010parietal or \u2018posterior\u2019 brain regions rather than memory difficulties characteristic of typical amnestic\u2010led Alzheimer's disease (a\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      ) attributed to medial temporal regions. Imaging and neuropathological studies suggest that PCA\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      is associated with a more posterior distribution of tau neurofibrillary tangles (NFTs), whereas \u03b2\u2010amyloid pathology (A\u03b2) is diffusely deposited throughout the cortex. This study characterised the neuropathological substrates of PCA\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      in comparison with a\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      , to further understanding of the biological basis of phenotypical heterogeneity in\n                      <jats:sc>AD<\/jats:sc>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Immunohistochemistry for A\u03b2; tau; the microglial markers CD68, CR3\u201043 and Iba1; \u03b1\u2010synuclein; and TDP\u201043 was carried out on 26 PCA\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      and 27 age and gender\u2010matched a\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      cases at the Queen Square Brain Bank. A\u03b2, tau and the three microglial markers were quantified in the superior frontal, superior temporal, superior parietal and occipital (primary visual cortex) cortices, with \u03b1\u2010synuclein and TDP\u201043 assessed using formal staging criteria. In addition, microglial circularity, a morphological indicator of microglial activation state, was calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a higher load of A\u03b2 and tau in the parietal region of PCA\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      compared to a\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      . In the PCA\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      compared to the a\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      group, there were significant increases in tau load in parietal and frontal relative to temporal regions. There was no difference in cerebral amyloid angiopathy (CAA) severity between PCA\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      and a\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      . There was a significantly lower temporal CD68 load in a\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      compared with PCA\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      . In a\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      , CD68 load was lowest and tau load highest in the temporal relative to all other regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study demonstrates differences in the distribution of A\u03b2 and tau and variations in regional neuroinflammatory response in PCA\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      and a\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      . These findings extend our understanding of the biological substrates underpinning PCA\u2010\n                      <jats:sc>AD<\/jats:sc>\n                      and highlight the potential for exploring phenotypic variants to understand selective vulnerability in neurodegenerative diseases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.70007","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T09:34:56Z","timestamp":1743759296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pathological Characterisation of Posterior Cortical Atrophy in Comparison With Amnestic Alzheimer's Disease"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8979-5262","authenticated-orcid":false,"given":"Z.","family":"Abdi","sequence":"first","affiliation":[{"name":"Department of Neurodegenerative Disease UCL Queen Square Institute of Neurology, University College London  London UK"},{"name":"The Queen Square Brain Bank for Neurological Disorders UCL Queen Square Institute of Neurology University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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