{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:13:53Z","timestamp":1791994433427,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Evidence suggests Alzheimer's disease (<jats:sc>AD<\/jats:sc>) patients are at increased risk of epilepsy and that seizure incidence is associated with faster cognitive decline. Previous studies indicate hyperphosphorylated tau may play a role in this disease association; however, abnormal TDP\u201043 and \u03b1\u2010synuclein deposition have not been extensively examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and neuropathological records of <jats:sc>AD<\/jats:sc> cases over a 5\u2010year period were retrieved from the London Neurodegenerative Diseases Brain Bank. The 114 cases were categorised into three groups: <jats:sc>AD<\/jats:sc> plus epilepsy, <jats:sc>AD<\/jats:sc> plus hippocampal sclerosis (HS) and AD only. Semi\u2010quantitative scores for tau, TDP\u201043 and \u03b1\u2010synuclein pathology within the middle temporal gyrus, hippocampus and amygdala were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 12% incidence of epilepsy and\/or epileptic symptomology was found among the cohort. Twelve cases (11%) showed HS. No significant difference in tau pathology scores was seen between groups. However, a significantly higher score for TDP\u201043 was seen in <jats:sc>AD<\/jats:sc> plus epilepsy compared with <jats:sc>AD<\/jats:sc> only in the middle temporal gyrus (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). The burden of \u03b1\u2010synuclein pathology was increased in the amygdala of <jats:sc>AD<\/jats:sc> plus epilepsy and <jats:sc>AD<\/jats:sc> plus HS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The incidence of epilepsy within this <jats:sc>AD<\/jats:sc> cohort is higher than expected within the general population (even when matched for age), and this may be associated with increased TDP\u201043 burden. Understanding the relationship between <jats:sc>AD<\/jats:sc> and epilepsy may highlight mechanisms of cellular damage and tissue vulnerability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/nan.70034","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T11:26:22Z","timestamp":1755861982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased Incidence of Epilepsy in a Brain Bank Alzheimer's Disease Cohort and Its Association With TDP\u201043 Pathology"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-1723","authenticated-orcid":false,"given":"Federica","family":"Rocca","sequence":"first","affiliation":[{"name":"London Neurodegenerative Diseases Brain Bank, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology &amp; Neuroscience King's College London  London 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Neuropathology King's College Hospital NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"King","sequence":"additional","affiliation":[{"name":"London Neurodegenerative Diseases Brain Bank, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology &amp; Neuroscience King's College London  London UK"},{"name":"Department of Clinical Neuropathology King's College Hospital NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Bodi","sequence":"additional","affiliation":[{"name":"London Neurodegenerative Diseases Brain Bank, Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology &amp; Neuroscience King's College London  London UK"},{"name":"Department of Clinical Neuropathology King's College Hospital NHS Trust  London 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