{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:17:57Z","timestamp":1791562677820,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T00:00:00Z","timestamp":1769299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171448"],"award-info":[{"award-number":["82171448"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201613"],"award-info":[{"award-number":["82201613"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Focal cortical dysplasia IIb (FCDIIb) and tuberous sclerosis complex (TSC) show persistent neuroinflammation that promotes epileptogenesis and epilepsy progression, suggesting that endogenous resolution of inflammation is inadequate to relieve neuronal network hyperexcitability. G\u2010protein\u2010coupled receptor 32 (GPR32) is a key regulator of inflammation resolution and we aimed to explore the roles of GPR32 in cortical lesions of patients with FCDIIb and TSC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We examined the expression and distribution of GPR32 in patients with FCDIIb and TSC and its effects on human microglial cell activation, inflammation and the electrophysiological properties of neurons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GPR32 and Resolvin D1 expression was significantly lower in cortical lesions of patients with FCDIIb and TSC than in controls and were negatively correlated with seizure frequency. GPR32 was widely distributed in neurons and microglia and was nearly absent in astrocytes. Furthermore, the Src homology region 2\u2010containing protein tyrosine phosphatase 2 (SHP2) pathway was downregulated in patients with FCDIIb and TSC. The GPR32\/SHP2\/nuclear factor\u2010kappa B pathway inhibited the M1 transformation of microglia to produce numerous pro\u2010inflammatory mediators and promoted M2 polarisation. GPR32 also regulated neuronal excitability by reducing the amplitude and frequency of spontaneous excitatory postsynaptic currents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that GPR32 may help control epilepsy in patients with FCDIIb and TSC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/nan.70062","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T05:35:02Z","timestamp":1769405702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["G Protein\u2010Coupled Receptor 32 Contributes to Inflammation Resolution and Neuronal Excitability Dysfunction in Patients With Focal Cortical Dysplasia IIb and Tuberous Sclerosis Complex"],"prefix":"10.1111","volume":"52","author":[{"given":"Kaixuan","family":"Huang","sequence":"first","affiliation":[{"name":"Epilepsy Research Center of PLA, Department of Neurosurgery Xinqiao Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Epilepsy Research Center of PLA, Department of Neurosurgery Xinqiao Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeng","family":"He","sequence":"additional","affiliation":[{"name":"Epilepsy Research Center of PLA, Department of Neurosurgery Xinqiao Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Epilepsy Research Center of PLA, Department of Neurosurgery Xinqiao Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingye","family":"Liu","sequence":"additional","affiliation":[{"name":"Epilepsy Research Center of PLA, Department of Neurosurgery Xinqiao Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhe","family":"Wan","sequence":"additional","affiliation":[{"name":"Epilepsy Research Center of PLA, Department of Neurosurgery Xinqiao Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Yang","sequence":"additional","affiliation":[{"name":"Epilepsy Research Center of PLA, Department of Neurosurgery Xinqiao Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxue","family":"Sang","sequence":"additional","affiliation":[{"name":"Epilepsy Research Center of PLA, Department of Neurosurgery Xinqiao Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujing","family":"Li","sequence":"additional","affiliation":[{"name":"Epilepsy Research Center of PLA, Department of Neurosurgery Xinqiao Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2024-5841","authenticated-orcid":false,"given":"Zhongke","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Armed Police Hospital of Chongqing  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2250-1693","authenticated-orcid":false,"given":"Shiyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Epilepsy Research Center of PLA, Department of Neurosurgery Xinqiao Hospital, Army Medical University (Third Military Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,25]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000175"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz411"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-019-02061-5"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12060"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-016-9142-0"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2019.01.392"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0217-x"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0546-2"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.02.040"},{"key":"e_1_2_14_11_1","first-page":"3130","article-title":"n\u20103 Docosapentaenoic Acid\u2010Derived Protectin D1 Promotes Resolution of Neuroinflammation and Arrests Epileptogenesis","volume":"141","author":"Frigerio F.","year":"2018","journal-title":"Brain"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.673549"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2012.02.003"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.249508"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145019"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-121735"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1354074"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115996"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.01.034"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.02.023"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.206084"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-03110-y"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/db23-0700"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12777"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13670"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01747.x"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr032"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12925"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2022.2032650"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.13065"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6884"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-02041-7"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136981"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101788"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1501701"},{"key":"e_1_2_14_36_1","article-title":"Time\u2010Dependent Protective and Pro\u2010Resolving Effects of FPR2 Agonists on Lipopolysaccharide\u2010Exposed Microglia Cells Involve Inhibition of NF\u2010\u03baB and MAPKs Pathways","volume":"10","author":"Tylek K.","year":"2021","journal-title":"CELLS\u2010BASEL"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00909.x"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2013.00373.x"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12345"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1414-7"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.70062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/nan.70062","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/nan.70062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T08:36:47Z","timestamp":1775723807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/nan.70062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,25]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/nan.70062"],"URL":"https:\/\/doi.org\/10.1111\/nan.70062","archive":["Portico"],"relation":{},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,25]]},"assertion":[{"value":"2024-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70062"}}