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<jats:list-item>\n                        <jats:p>Primary four\u2010repeat tauopathy can occur in individuals with lifelong severe intellectual disability.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Two autopsy cases demonstrated typical PSP and PSP\u2010like phenotypes with distinct pathological distributions.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Molecular autopsy identified variants in SPG7 and CTSD, suggesting intracellular quality\u2010control vulnerability and lysosomal dysfunction.<\/jats:p>\n                      <\/jats:list-item>\n                      <jats:list-item>\n                        <jats:p>Neurodevelopmental vulnerability and impaired intracellular degradation may modify late\u2010onset four\u2010repeat tauopathy.<\/jats:p>\n                      <\/jats:list-item>\n                    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